Isoliquiritigenin-cyclodextrin or cyclodextrin derivative inclusion compound and composition, preparation method and use
A technology of isoliquiritigenin and cyclodextrin is applied in the application field of deep processing of isoliquiritigenin, which can solve the problems of poor solubility, poor solubility, and poor absorption of isoliquiritigenin by the human body.
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Embodiment 1
[0030] Example 1: Preparation method of isoliquiritigenin-β-cyclodextrin inclusion compound
[0031] Take 1mmol of β-cyclodextrin, add 60g of water to dissolve, add 1mmol of isoliquiritigenin while stirring at room temperature, continue to stir, so that the β-cyclodextrin and isoliquiritigenin are completely reacted, after the reaction is completed, a solution is obtained, and The above solution was filtered with a microporous membrane, and the filtrate was pre-frozen in a -80°C refrigerator for 4 hours, and then dried overnight at -80°C with a freeze dryer to obtain a solid isoliquiritigenin-β-cyclodextrin inclusion compound.
Embodiment 2
[0032] Example 2: Preparation method of isoliquiritigenin-β-cyclodextrin inclusion compound
[0033] Take 10mmol of β-cyclodextrin, add 600g of water to dissolve, add 1mmol of isoliquiritigenin while stirring at room temperature, continue to stir, so that the β-cyclodextrin and isoliquiritigenin are completely reacted, after the reaction is completed, a solution is obtained, and The above solution was filtered with a microporous membrane, and the filtrate was pre-frozen in a -80°C refrigerator for 4 hours, and then dried overnight at -80°C with a freeze dryer to obtain a solid isoliquiritigenin-β-cyclodextrin inclusion compound.
Embodiment 3
[0034] Example 3: Preparation method of isoliquiritigenin-hydroxypropyl-β-cyclodextrin inclusion compound
[0035] Take 1mmol of hydroxypropyl-β-cyclodextrin, add 10g of water to dissolve, add 1mmol of isoliquiritigenin while stirring at room temperature, and continue stirring to completely react the hydroxypropyl-β-cyclodextrin and isoliquiritigenin, After the reaction is completed, a solution is obtained, and the above solution is filtered with a microporous membrane, and the filtrate is pre-frozen in a refrigerator at -80°C for 4 hours, and then dried overnight at -80°C with a freeze dryer to obtain solid isoliquiritigenin-hydroxypropyl-β - Cyclodextrin inclusion complexes.
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