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Medicinal composition with anti-fatigue effect as well as preparation method and application thereof

A composition and anti-fatigue technology, which is applied in the direction of drug combination, medical preparations containing active ingredients, applications, etc., can solve the problems of insignificant anti-fatigue effect, unsuitable for long-term consumption, and high price of Chinese patent medicines

Inactive Publication Date: 2012-12-19
YUNNAN YUNYAO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But at the same time, some medicinal materials are relatively expensive, resulting in high prices of Chinese patent medicines and a narrow audience; some anti-fatigue effects are not obvious or have toxic and side effects, so they are not suitable for long-term consumption
[0004] In view of the defects of current anti-fatigue drugs or health food such as high price, inaccurate curative effect, and large toxic and side effects, people pay more attention to finding, researching and developing ideal anti-fatigue drugs from traditional herbal medicines

Method used

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  • Medicinal composition with anti-fatigue effect as well as preparation method and application thereof
  • Medicinal composition with anti-fatigue effect as well as preparation method and application thereof
  • Medicinal composition with anti-fatigue effect as well as preparation method and application thereof

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preparation example Construction

[0026] The preparation method of the pharmaceutical composition with anti-fatigue effect of the present invention includes raw material preparation, water-soluble active ingredient preparation, alcohol-soluble active ingredient preparation, mixing and assembling process, specifically including:

[0027] A. Raw material preparation: prepare raw materials according to the formula and carry out pre-treatment according to the processing requirements of Chinese herbal medicine pieces for later use;

[0028] B. Preparation of water-soluble active ingredients: Put Radix Paeoniae Alba, Fructus Aurantii Fructus, Radix Polygoni Multiflori, Lotus Leaf and Agrimony into an extraction container, add 3 to 15 times the weight of water, extract 1 to 5 times, each time for 0.5 to 5 hours, and combine Extract and filter, concentrate the filtrate to obtain water extract with relative density of 1.02-1.10; add 1-10 times of ethanol solution with a weight concentration of 50-90% to the water extract,...

Embodiment 1

[0038] Take 400g of Radix Paeoniae Alba, 200g of Fructus Citrifolia, 100g of Radix Polygoni Multiflori, 50g of lotus leaves, and 150g of Agrimony into an ultrasonic preparation tank, add 13500g of demineralized water, and ultrasonically extract the medicinal materials for 5 hours to obtain the leachate, repeat the extraction 5 times, and then The extracts were combined and filtered to obtain the filtrate, and the filtrate was concentrated by distillation under reduced pressure to a water extract with a relative density of 1.02. Add 1 times the weight concentration of 50% ethanol to the water extract, refrigerate and stand at 0°C for 48 hours, take the supernatant and filter, and distill the filtrate under reduced pressure to obtain a refined water extract with a relative density of 1.02. Take 10 g of Panax notoginseng and crush it to a particle size of 1 mm, put it in an ultrasonic preparation tank, add 120 g of 60% ethanol solution, and conduct ultrasonic extraction for 5 hour...

Embodiment 2

[0040] Take 1000g of Radix Paeoniae Alba, 600g of Fructus Citrifolia, 300g of Radix Polygoni Multiflori, 240g of lotus leaves, and 500g of Agrimony into the electromagnetic wave preparation tank, add 7920g of deionized water, and extract the medicinal materials with electromagnetic waves for 0.5 hours to obtain the leachate, and repeat the extraction 3 times. Then the leachate is combined and filtered to obtain a filtrate, and the filtrate is concentrated with a 1000 molecular weight membrane to a water-extracted extract with a relative density of 1.1. Add 10 times the weight concentration of 90% ethanol to the extract, refrigerate and stand at 15°C for 6 hours, take the supernatant and filter, and the filtrate 500 molecular weight membrane is concentrated into a refined water extract with a relative density of 1.25. Take 400g of Panax notoginseng and crush it to a particle size of 20mm and place it in an ultrasonic preparation tank, add 80g of ethanol solution with a concentra...

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Abstract

The invention discloses a medicinal composition with an anti-fatigue effect as well as a preparation method and an application thereof. The medicinal composition comprises the following components in parts by weight: 8 to 50 parts of white paeony root, 4 to 30 parts of fructus aurantii, 2 to 15 parts of prepared polygonum multiflorum, 1 to 12 parts of lotus leaf, 3 to 25 parts of hairyvein agrimony and 2 to 20 parts of pseudo-ginseng. The method comprises the following steps of: preparing raw materials, preparing water-soluble active ingredients, preparing alcohol-soluble active ingredients and mixing and matching. A pharmaceutically acceptable carrier and / or an excipient are / is added into the medicinal composition to prepare pills, paste, sublimed preparation, tablets, capsules, oral liquid, powder and electuary. The medicinal composition is applied to preparing foods or medicines with the effects of relieving fatigue and / or treating mental fatigue and exercise induced fatigue. The medicinal composition is reasonable in formula, easy and convenient in preparation and accurate in curative effect. Due to the mouse toxicity and mental fatigue and exercise induced fatigue load swimming test, the medicinal composition does not have toxic or side effect and has obvious effects of relieving and eliminating the fatigues.

Description

technical field [0001] The invention belongs to the technical field of biopharmaceuticals, and specifically relates to a pharmaceutical composition with anti-fatigue effect, which has reasonable prescription, convenient preparation, definite curative effect and no toxic or side effects, and its preparation method and application. Background technique [0002] Fatigue is a subjective feeling of discomfort. It is a common and frequently-occurring disease in clinical practice. It belongs to the sub-health category and involves the internal organs, mainly the spleen, liver and kidney. Modern Chinese medicine believes that fatigue is caused by the dual factors of deficiency of vitality and mental changes (or unsmooth). In treatment, it is not only necessary to invigorate the deficiency and strengthen the body, but also to dispel fatigue and soothe the nerves. On the one hand, tonify the deficiency and strengthen the vitality, nourish the body, replenish the deficiency, make it r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/752A23L1/29A61P1/14A61P25/00A61P39/06A23L33/00
Inventor 王永炎
Owner YUNNAN YUNYAO TECH
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