Receiving device for electrospun tissue-engineered blood vessels with nonlinear mechanical properties
An electrospinning and tissue engineering technology, applied in the field of tissue engineering blood vessel preparation, can solve the problem of low performance matching
Inactive Publication Date: 2019-09-24
ZHENGZHOU UNIV
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Problems solved by technology
[0004] The present invention proposes a receiving device for electrospun tissue engineering blood vessels with nonlinear mechanical properties, which solves the problem that the matching degree of tissue engineering blood vessels grown in the prior art and real blood vessels is not high
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[0024] Concrete embodiment: configuration 10% concentration polylactic acid (PLA) spinning solution utilizes this example device to receive, and the distance between the rotating shaft and the moving shaft is 3cm, and the period of the moving shaft moving in the horizontal plane is 2 seconds, and the amplitude is 1.5cm , the angular velocity of the axis of rotation is 2rad / s. The macroscopic morphology of the final prepared blood vessel is as follows: Figure 8 As shown, the microscopic morphology and mechanical properties are as follows Figure 6 and Figure 7 shown.
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The invention provides an electrostatic spinning tissue engineering blood vessel receiving device having nonlinear mechanical performance and solves the problem of low performance matchability between grown tissue engineering blood vessels and real blood vessels. The receiving device comprises a propeller which is connected with a spinning nozzle, an electrostatic high-voltage applying device is arranged at the spinning nozzle, and a collection device is arranged at the spinning nozzle and comprises a rotating shaft and a moving shaft moving back and forth in a horizontal plane. In the prior art, stress strain curve of tissue engineering blood vessels prepared by electrostatic spinning technology has a gap with needs of the real blood vessels, and a main reason is that the tissue engineering blood vessels have no low-stress large-strain areas. By improving the receiving device to enable collected fiber to be bent by a certain degree, prepared blood vessels are enabled to realize areas I at the early stage of deformation by straightening bent portions of the fiber, and blood vessels can expand greatly under small stress to adapt to the circumstance of momentary blood flow increase.
Description
technical field [0001] The invention relates to the field of tissue engineering blood vessel preparation, in particular to a device for preparing engineered blood vessels by electrospinning technology. Background technique [0002] Cardiovascular disease is the number one killer of human health, and tissue engineered blood vessels are ideal for replacing or regenerating blood vessels in diseased areas. Among the preparation processes of tissue engineering blood vessels, electrospinning technology is favored by scholars because of its simple operation, high product porosity, and nanostructure suitable for cell growth. The preparation principle is as follows: figure 1 shown. The polymer solution is transported to the spinneret 3 by the propeller 2, and the electrostatic high voltage applied by the spinneret 3 makes the polymer solution with a certain viscosity start to split into fibers (with a diameter of several hundred nanometers) under the action of electric field repulsi...
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IPC IPC(8): D01D5/00A61L27/18A61L27/50
Inventor 王小峰李倩徐轶洋牛宗武高艳红李旭燕蒋晶蒋林侯建华
Owner ZHENGZHOU UNIV
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