Three-dimensional passive imaging method and system for brain focusing ultrasonic cavitation real-time monitoring

Abstract

The invention provides a three-dimensional passive imaging method and system for brain focusing ultrasonic cavitation real-time monitoring. On the basis of calibrating cavitation signal distortion due to skull shielding, array elements of a surface array in two directions are subjected to robust Capon beamforming so as to greatly inhibit the interference from other directions and the mutual action between cavitation microbubbles; on the basis of the differences among phases of cavitation signals, a phase correlation coefficient is introduced for correcting a beamforming algorithm, so that the imaging resolution ratio is improved during the imaging artifact inhibition; and finally, a three-dimensional cavitation body is subjected to processing such as data thresholding and smoothening. The method and the system can solve the problems that the detection sensitivity of a conventional magnetic resonance and active ultrasonic imaging monitoring method on the cavitation is insufficient; the real-time monitoring cannot be realized by the active ultrasonic imaging monitoring; and the performance of a conventional passive imaging method is limited, and the like. A real-time monitoring measure for the cavitation effect in the brain focusing ultrasonic treatment process is provided for the clinics, so that the real-time feedback and control of the grain treatment becomes possible.

Description

technical field [0001] The invention belongs to the technical field of ultrasonic detection and ultrasonic imaging, in particular to a three-dimensional passive imaging method and system suitable for real-time monitoring of brain focused ultrasonic cavitation. Background technique [0002] The cavitation effect refers to the dynamic process of expansion, contraction and collapse of the cavitation nucleus in the medium under the action of some external physical fields (such as ultrasonic field, laser field, microwave field). Focused ultrasound therapy of the brain mainly utilizes the cavitation effect of encapsulated microbubbles under ultrasound excitation to achieve the purpose of treating brain diseases. Previous studies have shown that the main mechanism of focused ultrasound combined with microbubbles to open the blood-brain barrier is the cavitation effect. Under low sound pressure, microbubbles undergo steady-state cavitation. It interacts with capillaries to separate...

AI Technical Summary

Problems solved by technology

[0006] In view of the insensitivity of magnetic resonance imaging to the detection of brain cavitation microbubble signals, the mutual restriction of the detection depth and detection sensitivity of traditional B-mode and plane wave active imaging, and the inability to monitor the cavitation effect in the process of focused ultrasound, and the existing two-dimensional Passive imaging technology has problems such as low resolution, high artifacts, and inability to provide cavitation three-dimensional space information. The purpose of the present invention is to provide a three-dimensional passive imaging method for real-time monitoring of brain focused ultrasound cavitation and system

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