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Traditional Chinese medicine composition and application thereof

A composition and technology of traditional Chinese medicine, applied in the field of medicine, can solve problems such as breast cancer proliferation and recurrence that are not well treated and controlled

Inactive Publication Date: 2017-11-17
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there are no good drugs for the treatment and control of breast cancer proliferation and recurrence

Method used

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  • Traditional Chinese medicine composition and application thereof
  • Traditional Chinese medicine composition and application thereof
  • Traditional Chinese medicine composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0065] The preparation process of the traditional Chinese medicine composition of the present invention is to grind Hedyotis diffusa and Scutellaria barbata into powder, decoct with water for several times, combine the extracts, and concentrate them into extracts. The resulting extract was degreased with petroleum ether and extracted with ethyl acetate.

[0066] Subsequent drug efficacy experiments will prove that the traditional Chinese medicine composition of the present invention can replace chemotherapy drugs to prevent and treat breast cancer, osteoporosis, inflammation and inhibit the activity of tumor-related macrophages.

[0067] The traditional Chinese medicine composition of the present invention is a pure natural plant extract used both as medicine and food, and simultaneously exerts effects on breast cancer cell proliferation, tumor immune response cell activity, osteoclast differentiation and inflammation.

[0068] The traditional Chinese medicine composition of t...

Embodiment 1

[0077] Embodiment 1 The preparation embodiment of Chinese medicine composition (YDW11) of the present invention

[0078] Take 500 grams of Hedyotis diffusa and 500 grams of Scutellaria barbata (compatibility at a weight ratio of 1:1), crush them, decoct them with water for 4 times, combine the extracts, concentrate to obtain 189.68 grams of extracts, and dissolve the obtained extracts in pure water , extracted 6 times with equal volume of petroleum ether for degreasing, the water phase was concentrated and freeze-dried to a constant weight of 134.6 grams, the degreased water extract was dissolved in pure water, and extracted 6 times with ethyl acetate to obtain an extract, which was concentrated Dried extract 0.28 g (YDW11)

Embodiment 2

[0079] Embodiment 2 The experimental research of Chinese medicine composition (YDW11) anti-breast cancer of the present invention

[0080] 2.1. MTT method to investigate the effect of YDW11 on the proliferation activity of normal human breast epithelial cells 10A1 and human breast cancer cell lines MDA-MB-231, BT549, and HS578T in vitro

[0081] 10A1 and MDA-MB-231 cells were seeded in 96-well plates at 5000 / 100 μL, BT549 cells were seeded at 2500 / 100 μL, and HS578T cells were seeded at 2000 / 100 μL in 96-well plates, and cultured overnight. YDW11 in 25, 50 μg·mL -1 Dosage treatment of cells, after treatment for 24H, 48H, and 72H, MTT was added to each well (dissolved in PBS to 5 mg·mL -1 ) 10 μL, continued to culture for 4 hours, discarded the supernatant, added 100 μL of DMSO, placed on a shaker until the crystals were completely dissolved, read the absorbance value A at 490 nm, and calculated the effect of each dose of YDW11 treatment groups on cell viability. Three replic...

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PUM

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Abstract

The invention relates to the field of medicines, in particular to traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following raw materials: herba hedyotis diffusae and herba scutellariae barbatae in a weight ratio of 1:1 through steps as follows: the herba hedyotis diffusae and the herba scutellariae barbatae are ground, decocted with water for 3-5 times, extract liquids are mixed and concentrated, and an extract is obtained and degreased with petroleum ether and extracted with ethyl acetate for 1-6 times. The pharmaceutical composition can resist breast cancer, osteoporosis and inflammation, and inhibit activity of tumor-associated macrophages.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a traditional Chinese medicine composition and its medical application. Background technique [0002] Breast cancer is a malignant tumor that occurs in the glandular epithelial tissue of the breast. Free cancer cells can spread throughout the body with blood or lymph fluid, forming distant metastasis such as bone metastasis, brain metastasis, and lung metastasis, which is life-threatening. So far, there are no good drugs for treating and controlling the proliferation and recurrence of breast cancer. [0003] In the comprehensive treatment of breast cancer, traditional Chinese medicine has significant advantages in relieving postoperative symptoms and complications, reducing the toxic and side effects of radiotherapy and chemotherapy, and resisting recurrence and metastasis. [0004] Tumor associated macrophages (Tumor associated macrophages, referred to as TAM) generally refer to macroph...

Claims

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Application Information

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IPC IPC(8): A61K36/748A61P15/14A61P35/00A61P31/00A61P29/00A61P19/08A61K36/539
CPCA61K36/539A61K36/748A61K2236/331A61K2236/35A61K2236/39A61K2236/55A61K2300/00
Inventor 章丹丹黄爽张卫东田新慧
Owner SHANGHAI UNIV OF T C M