Safe, efficient and energy-saving technological process for extracting artemisinin or artemisia annua extract

A high-efficiency, energy-saving, technological process technology, applied in the direction of organic chemistry, can solve the problem of low safety factor, achieve the effect of reducing steam and power consumption, saving solvent, and ensuring safety

Inactive Publication Date: 2017-11-24
YUZHOU TIANYUAN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] At present, whether it is laboratory or industrial production of artemisinin or artemisinin paste, it is extracted by flammable and explosive organic solvents such as petroleum ether, ether, methanol or ethanol, which has a very low safety factor, and most of the methods are intermittent. After multiple extractions, the extracts are combined and then concentrated to produce artemisinin or artemisinin paste, or the method of continuous extraction and then concentration

Method used

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  • Safe, efficient and energy-saving technological process for extracting artemisinin or artemisia annua extract

Examples

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Embodiment 1

[0028] A safe, high-efficiency and energy-saving technological process for extracting artemisinin paste or artemisinin, comprising the following steps:

[0029] A. Add Artemisia annua leaves from the feed valve 13 of the percolation tank to the percolation tank 1, then add dichloromethane to completely submerge the leaves of Artemisia annua in the percolation tank, and then open the heating valve 8 of the percolation tank to heat the temperature. When the temperature reaches 35-40°C, turn on the ultrasound source 5 for ultrasound;

[0030] B. After half an hour of ultrasonication, open the discharge valve 14 of the percolation tank and the feed valve 16 of the concentration tank, so that the percolation liquid in the percolation tank 1 enters the concentration tank 3. When the percolation liquid in the concentration tank 3 reaches When 80% of its volume, open the enrichment tank heating valve 10 and start to concentrate;

[0031] C, open the cooling circulating water while op...

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Abstract

The invention discloses a safe, efficient and energy-saving technological process for extracting artemisinin or artemisia annua extract. The technological process comprises the following steps: adding the leaves of sweet wormwood into a percolation tank; adding dichloromethane to completely immerse the leaves of sweet wormwood; opening a steam valve for heating; opening an ultrasonic source for ultrasonic treatment; after half hour of ultrasonic treatment, enabling the percolate in the percolation tank to enter a concentration tank for concentration. According to the technological process disclosed by the invention, by adopting non-flammable dichloromethane as a solvent and performing the ultrasonic treatment, percolation and concentration at the same time, the production safety is ensured while the solvent can be remarkably saved, and the consumption of steam and power is substantially reduced.

Description

technical field [0001] The invention belongs to the technical field of artemisinin extraction, and in particular relates to a safe, high-efficiency and energy-saving process for extracting artemisinin paste or artemisinin. Background technique [0002] At present, whether it is laboratory or industrial production of artemisinin or artemisinin paste, it is extracted by flammable and explosive organic solvents such as petroleum ether, ether, methanol or ethanol, which has a very low safety factor, and most of the methods are intermittent. After multiple extractions, the extracts are combined and then concentrated to produce artemisinin or Artemisia annua paste, or the method of continuous extraction and then concentration is adopted. [0003] The present invention does not use flammable and explosive organic solvents such as diethyl ether or petroleum ether for extraction, but uses nonflammable low-boiling dichloromethane as a solvent. This method is not only safe, but also mo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/18C07D493/20
CPCC07D493/18C07D493/20
Inventor 赵冠瑜
Owner YUZHOU TIANYUAN BIOTECH CO LTD
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