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Pharmaceutical composition containing prunella vulgaris polysaccharides, triterpenes, and volatile oil, and applications thereof

A composition and technology of Prunella vulgaris, applied in the directions of drug combination, medical preparations containing active ingredients, anti-tumor drugs, etc., can solve the problems of affecting the quality of life of patients, large toxic and side effects, etc., to achieve a balanced immune microenvironment, inhibit Growth, Effects of Altering Growth and Living Environment

Active Publication Date: 2017-12-08
HUNAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The current breast treatment methods mainly include surgical resection, chemotherapy, radiotherapy, endocrine therapy and molecular targeted therapy, but all of them have huge toxic and side effects and affect the quality of life of patients.
Traditional Chinese medicine has unique advantages in the treatment of breast cancer. Prunella vulgaris has been used in the treatment of mammary gland hyperplasia since ancient times. However, the current research and application of Prunella vulgaris are mostly focused on extracts and monomer components, but there is no combination of effective components for breast cancer. cancer treatment

Method used

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  • Pharmaceutical composition containing prunella vulgaris polysaccharides, triterpenes, and volatile oil, and applications thereof
  • Pharmaceutical composition containing prunella vulgaris polysaccharides, triterpenes, and volatile oil, and applications thereof
  • Pharmaceutical composition containing prunella vulgaris polysaccharides, triterpenes, and volatile oil, and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A kind of pharmaceutical composition of embodiment 1

[0032] 1. Raw materials:

[0033] Prunella vulgaris polysaccharide: Grind Prunella vulgaris, weigh 500g, heat and reflux extract 4 times with 10 times the amount of water, combine the extracts, centrifuge at 4800r / min to remove impurities, concentrate under reduced pressure to 2L, add 95% ethanol to make the final concentration of ethanol reach 70 %, alcohol precipitation in a refrigerator at 4°C for 24h, and then centrifuged (4800r / min, 10min), the supernatant was discarded, and the resulting precipitate was washed twice with absolute ethanol, acetone, and anhydrous ether successively, and then heated at 55°C Vacuum drying under the condition to obtain the crude polysaccharide of Prunella vulgaris. The extraction rate is about 7.5%-9.5%.

[0034] Prunella vulgaris triterpenes: Grind Prunella vulgaris, weigh 500g, heat and reflux extract 4 times with 10 times the amount of water, combine the extracts, centrifuge a...

Embodiment 2

[0039] The difference between this example and Example 1 is that the active ingredient content of Prunella vulgaris polysaccharide, triterpene, and volatile oil is calculated according to the extraction rate, and the drug is obtained according to the combination of advantages and disadvantages with an effective content ratio of 5:1:2.

Embodiment 3

[0041] The difference between this example and Example 1 is that the active ingredient content of Prunella vulgaris polysaccharide, triterpene, and volatile oil is calculated according to the extraction rate, and the drug is obtained according to the combination of advantages and disadvantages with an effective content ratio of 3:3:1.

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PUM

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Abstract

The invention belongs to the field of pharmaceutical composition, and more specifically discloses a pharmaceutical composition containing prunella vulgaris polysaccharides, triterpenes, and volatile oil. It is found via experiments that combination of prunella vulgaris polysaccharides, triterpenes, and volatile oil is capable of increasing antiproliferative activity and anti-tumor activity, inducing and promoting apoptosis of breast cancer cells effectively, and improving body immunity. The combination is capable of improving the anti-tumor activity of single ingredient, reducing drug using amount effectively, and reducing drug adverse reaction.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition containing prunella vulgaris polysaccharide, triterpenes and volatile oil. Background technique [0002] The genus Prunella is a perennial herb of the Labiatae family, and there are about 15 species in the world, which are widely distributed in temperate regions and tropical mountainous regions of Eurasia, Northwest Africa and North America. my country is mainly distributed in the Huaihe River Basin and the middle and lower reaches of the Yangtze River. Jiangsu, Anhui, Zhejiang and Henan have the most abundant wild resource reserves. The compounds contained mainly include triterpenes and their saponins, phenolic acids, sterols and their glycosides, flavonoids, Organic acids, volatile oils and sugars, etc. [0003] The current breast treatment methods mainly include surgical resection, chemotherapy, radiotherapy, endocrine therapy and molecular targeted ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/536A61P35/00A61P37/04A61K31/715
CPCA61K31/715A61K36/536A61K2236/331A61K2236/37A61K2236/39A61K2300/00
Inventor 林丽美廖端芳闫庆梓
Owner HUNAN UNIV OF CHINESE MEDICINE