Unlock instant, AI-driven research and patent intelligence for your innovation.

Pharmaceutical composition containing Prunella vulgaris polysaccharide, triterpene and volatile oil and its application

A technology of Prunella vulgaris and volatile oil, applied in the field of pharmaceutical compositions of triterpenes and volatile oils, and containing Prunella vulgaris polysaccharide, can solve the problems of affecting the quality of life of patients, large toxic and side effects, etc., and achieve a balanced immune microenvironment, inhibit growth, and delay The effect of the development process

Active Publication Date: 2021-04-16
HUNAN UNIV OF CHINESE MEDICINE
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The current breast treatment methods mainly include surgical resection, chemotherapy, radiotherapy, endocrine therapy and molecular targeted therapy, but all of them have huge toxic and side effects and affect the quality of life of patients.
Traditional Chinese medicine has unique advantages in the treatment of breast cancer. Prunella vulgaris has been used in the treatment of mammary gland hyperplasia since ancient times. However, the current research and application of Prunella vulgaris are mostly focused on extracts and monomer components, but there is no combination of effective components for breast cancer. cancer treatment

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pharmaceutical composition containing Prunella vulgaris polysaccharide, triterpene and volatile oil and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A kind of pharmaceutical composition of embodiment 1

[0028] 1. Raw materials:

[0029] Prunella vulgaris polysaccharide: Grind Prunella vulgaris, weigh 500g, heat and reflux extract 4 times with 10 times the amount of water, combine the extracts, centrifuge at 4800r / min to remove impurities, concentrate under reduced pressure to 2L, add 95% ethanol to make the final concentration of ethanol reach 70 %, alcohol precipitation in a refrigerator at 4°C for 24h, and then centrifuged (4800r / min, 10min), the supernatant was discarded, and the resulting precipitate was washed twice with absolute ethanol, acetone, and anhydrous ether successively, and then heated at 55°C Vacuum drying under the condition to obtain the crude polysaccharide of Prunella vulgaris. The extraction rate is about 7.5%-9.5%.

[0030] Prunella vulgaris triterpenes: Grind Prunella vulgaris, weigh 500g, heat and reflux extract 4 times with 10 times the amount of water, combine the extracts, centrifuge a...

Embodiment 2

[0035] The difference between this example and Example 1 is that the active ingredient content of Prunella vulgaris polysaccharide, triterpene, and volatile oil is calculated according to the extraction rate, and the drug is obtained according to the combination of advantages and disadvantages with an effective content ratio of 5:1:2.

Embodiment 3

[0037] The difference between this example and Example 1 is that the active ingredient content of Prunella vulgaris polysaccharide, triterpene, and volatile oil is calculated according to the extraction rate, and the drug is obtained according to the combination of advantages and disadvantages with an effective content ratio of 3:3:1.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a pharmaceutical composition, and specifically discloses a pharmaceutical composition containing prunella vulgaris polysaccharide, triterpene and volatile oil. The present invention has found through experimental research that the Prunella vulgaris polysaccharides, triterpenes and volatile oils can significantly improve the anti-proliferation activity and anti-tumor activity after being used in combination, and can effectively induce and promote the apoptosis of breast cancer cells, and enhance the body's Immune Function. Since the above-mentioned compatibility can enhance the antitumor activity of a single drug, the above-mentioned compatibility can also effectively reduce the dosage of the drug and reduce the adverse reaction of the drug.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition containing prunella vulgaris polysaccharide, triterpenes and volatile oil. Background technique [0002] The genus Prunella is a perennial herb of the Labiatae family, and there are about 15 species in the world, which are widely distributed in temperate regions and tropical mountainous regions of Eurasia, Northwest Africa and North America. my country is mainly distributed in the Huaihe River Basin and the middle and lower reaches of the Yangtze River. Jiangsu, Anhui, Zhejiang and Henan have the most abundant wild resource reserves. The compounds contained mainly include triterpenes and their saponins, phenolic acids, sterols and their glycosides, flavonoids, Organic acids, volatile oils and sugars, etc. [0003] The current breast treatment methods mainly include surgical resection, chemotherapy, radiotherapy, endocrine therapy and molecular targeted ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/715A61K36/536A61P35/00A61P37/04
CPCA61K31/715A61K36/536A61K2236/331A61K2236/37A61K2236/39A61K2300/00
Inventor 林丽美廖端芳闫庆梓
Owner HUNAN UNIV OF CHINESE MEDICINE