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Optical microvascular current flow imaging method

An imaging method and microvascular technology, applied in the field of blood flow imaging, can solve problems such as low sensitivity, and achieve the effects of improving signal-to-noise ratio, enhancing reflection and scattering signals, and reducing optical noise

Inactive Publication Date: 2017-12-08
INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
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Problems solved by technology

[0016] The sensitivity of the OMAG algorithm depends on the angle of incidence, and when most vessels are perpendicular to the OCT sample arm, such as the retinal microcirculation, algorithms that rely on phase information have very low sensitivity

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  • Optical microvascular current flow imaging method

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[0090] Example: Optical Fundus Blood Flow Image

[0091] The high-speed spectrum acquisition system of the OCT system is used to perform high-speed 3D acquisition of scattered light with static tissue and dynamic blood flow information reflected by tissue and intravascular blood flow. By optimizing the scanning speed and scanning mode of the imaging beam, the X-direction acquisition m A-lines form a B-Scan, n connected positions are collected in the Y direction, and each position is collected h times repeatedly, and h*n B-Scans are continuously collected to form 3D volume data. The process of optical fundus blood flow imaging is as follows: Figure 5 shown.

[0092] Figure 5 The middle a fundus optical OCT structure image includes: (1) firstly registering image a to generate image b; (2) superimposing grayscale images on image b to generate image d; (3) performing temporal coherent light on image b The speckle contrast processing is performed to generate an image c; (4) th...

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Abstract

The invention relates to an optical microvascular blood flow imaging method. The method includes the following steps that: data acquisition is performed, an OCT (Optical Coherence Tomography) system is adopted to perform original spectral signal acquisition, k-space transformation, interpolating operation and Fourier transformation so as to generate B-Scan images; image registration is performed; image grayscale superimposed averaging is performed; time speckle contrast processing is performed, each pixel in space of h registered images is corresponding to a time series of light intensity change, the temporal contrast statistics of the time series is performed, the temporal contrast of the pixel is obtained, and the same processing is performed on each pixel in space, and the temporal contrast image of the image group is obtained by means of statistics; and image marking is performed. With the optical microvascular blood flow imaging method of the invention adopted, background random scattered light noises can be reduced, tissue structure and microvascular blood flow reflection signals and scattering signals are enhanced, and therefore, a signal-to-noise ratio is improved; and tissue structure static position and dynamic blood flow position information is obtained; and a blood flow image is obtained.

Description

technical field [0001] The present invention relates to a blood flow imaging method. In particular, it relates to an optical microvascular blood flow imaging method. Background technique [0002] The pathology and vascular morphology of many biological tissues are closely related to the changes of tissue microcirculation. Current imaging methods have several limitations, including being invasive (eg, radiometric methods), unable to provide three-dimensional (3D) information (eg, laser speckle contrast imaging), low spatial and temporal resolution (eg, MRI) or Limited imaging depth (eg, multiphoton microscopy, which has an imaging depth of <300 μm). Optical coherence tomography (Optical Coherence Tomography, OCT) is a new type of non-destructive optical imaging technology developed in the early 1990s. It uses the basic principle of weak coherent light interferometer to detect the back-reflection or scattering signals of the incident weak coherent light at different dept...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06T7/33G06T11/00A61B5/00
CPCA61B5/0066G06T7/33G06T11/008G06T2207/30101
Inventor 李跃杰王立伟李易陆
Owner INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI