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Method, system and device for terahertz imaging of biological tissue based on multi-scale entropy

A technology of terahertz imaging and multi-scale entropy, which is applied in the directions of instruments, applications, diagnostic recording/measurement, etc., can solve the problems that the contrast needs to be further improved significantly, and the imaging discrimination degree of terahertz signal utilization needs to be further improved, so as to achieve imaging contrast. improved effect

Active Publication Date: 2020-11-03
BEIJING INSTITUTE OF TECHNOLOGYGY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, unlike common biological macromolecules with typical absorption peaks, biological tissues have no obvious characteristic absorption peaks in the terahertz band. Imaging contrast needs to be further significantly improved, especially when the signal-to-noise ratio of the imaging system is low
Moreover, the existing methods for terahertz imaging of biological tissues often only use information at a certain time point or frequency point, and the utilization rate of the entire terahertz signal and the corresponding imaging discrimination need to be further improved

Method used

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  • Method, system and device for terahertz imaging of biological tissue based on multi-scale entropy
  • Method, system and device for terahertz imaging of biological tissue based on multi-scale entropy
  • Method, system and device for terahertz imaging of biological tissue based on multi-scale entropy

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Embodiment 1

[0054] The above and other technical features and advantages of the present invention will be described in more detail below with reference to the accompanying drawings and embodiments.

[0055] figure 1 and figure 2 They are respectively the flow chart of calculating the multi-scale entropy of the terahertz time-domain signal at a certain point on the biological tissue sample in the present invention, and an exemplary schematic diagram of coarse-graining the time-domain signal when the scale is set to 3, setting x={ x 1 ,x 2 ,...,x N} represents a terahertz time-domain signal of length N, Represents the kth coarse-grained time series when the scale is τ, and the corresponding amplitude of the jth point is "INT" means take the integer part of . When the scale is τ, the entropy value of this point on the biological tissue is the average value of sample entropy values ​​of τ coarse-grained time series, which is calculated by the following formula, namely

[0056] ...

Embodiment 2

[0063] In yet another specific embodiment, the present invention also provides a biological tissue terahertz imaging system based on multi-scale entropy, which includes:

[0064] an imaging module, which performs two-dimensional imaging on the tested sample to obtain terahertz time-domain signals of each point on the tested sample;

[0065] The entropy value calculation module is used to calculate the multi-scale entropy of the terahertz time-domain signal of each point, and obtain the entropy value of each point on the sample under different scales;

[0066] The image reconstruction module selects the entropy value at a specific scale to reconstruct the terahertz image of the sample under test; and sums the entropy values ​​at multiple scales to reconstruct the terahertz image of the sample under test Terahertz images;

[0067] The result comparison module is used to display and compare the reconstructed terahertz images of different samples under test.

[0068] In a specif...

Embodiment 3

[0079] In yet another specific embodiment, the present invention also provides a biological tissue terahertz imaging device based on multi-scale entropy, which includes:

[0080] Display for displaying images and processing results;

[0081] A memory, and a processor connected to the display and the memory, the processor is configured to:

[0082] Receive the terahertz time-domain signal of each point on the tested sample obtained by two-dimensional imaging of the tested sample;

[0083] And calculating the multi-scale entropy of the terahertz time-domain signal at each point, to obtain the entropy values ​​of each point on the sample under different scales;

[0084] as well as,

[0085] Selecting the entropy value at a specific scale to reconstruct the terahertz image of the sample under test; summing up the entropy values ​​at multiple scales to reconstruct the terahertz image of the sample under test.

[0086] It should be noted that the device in this embodiment can exe...

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Abstract

The invention discloses a biological tissue terahertz imaging method, system and equipment based on multiscale entropy. According to the method, the information of whole terahertz time-domain spectroscopy signals is utilized, and the entropy value of each point on the detected biological tissue sample on different time scales is obtained; the entropy value on a certain scale is selected, or the entropy values on multiple scales are added together, so that a terahertz image of the detected biological tissue sample is reconstructed. By means of the method, the limitations that a traditional biological tissue terahertz imaging method only uses the spectroscopy information of a certain time or frequency point are overcome, and imaging contrast among different samples is improved.

Description

technical field [0001] The present invention relates to the application field of biological tissue imaging of terahertz waves, in particular to a method, system and device for biological tissue terahertz imaging based on multi-scale entropy. Background technique [0002] Terahertz waves have the characteristics of low photon energy, strong penetrability, and spectrum coverage of vibration and rotational energy levels of organic and biological macromolecules. Application prospect. And its imaging equipment is simpler and more portable than magnetic resonance imaging and computerized tomography imaging, and can be used for real-time navigation of medical operations. Terahertz imaging, as an emerging means of studying biological tissue properties and imaging recognition, has attracted more and more attention. [0003] Terahertz imaging has been applied to the imaging of various biological tissue samples such as animal tissues, human teeth, bones, breast cancer, skin and melan...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/05G01N21/3586
CPCA61B5/0507A61B5/7235G01N21/3586
Inventor 张锐张亮亮赵跃进
Owner BEIJING INSTITUTE OF TECHNOLOGYGY
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