Application of HOXA9 gene in preparation of drugs for treatment of cutaneous squamous cell carcinoma

Abstract

Belonging to the field of gene therapy, the invention discloses application of HOXA9 gene in preparation of drugs for treatment of cutaneous squamous cell carcinoma (CSCC). The inventor and the whole team carry out two years of experimental study, adopt cutaneous squamous cell carcinoma characteristic cell line A431 as the experimental object, and perform experiments to find that targeted up-regulation of HOXA9 can inhibit the tumor cell proliferation, migration and invasion ability, also can inhibit tumor cell glycolysis, and ultimately improve or treat cutaneous squamous cell carcinoma. The invention provides a new method for treatment of CSCC on the basis of maximum guarantee of complete organ functions and beautiful appearance, and the method can overcome the shortcomings of the existing technology and has great significance.

Description

Technical field [0001] The invention belongs to the field of gene therapy, and specifically relates to the application of HOXA9 gene in the preparation of drugs for treating skin squamous cell carcinoma. Background technique [0002] Cutaneous squamous cell carcinoma (Cutaneous squamous cell carcinoma, CSCC) is a type of malignant tumor originating from the epidermal appendage keratinocytes. It is one of the most common skin malignancies in clinical practice. Its incidence is second only to basal cell carcinoma, accounting for 20% of skin malignancies. The high incidence of CSCC in my country is 50-60 years old, and it is more common in exposed positions such as the head, neck, hands and forearm extension. The cause of CSCC is complex, and long-term UV exposure is its biggest risk factor. In addition, human papillomavirus (HPV) types 16, 18 and 31 infection, organ transplantation, chemical agents and other factors are closely related to its pathogenesis. Although the mortality...

AI Technical Summary

Problems solved by technology

In view of the fact that the operation of the traditional treatment method needs to expand the scope of resection to the surrounding tissue of the tumor, it is likely to cause damage to the function of the epidermis and subcutaneous tissue and affect the appearance of the organ. At the same time, the high recurrence rate of this method also makes it necessary to find a method that can maximize the protection of the organ. New methods of treating CSCC on the basis of intact function and beautiful appearance are imperative

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