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Application of kinsenoside to preparation of anti-fatigue medicine

A kind of clematis glucoside and anti-fatigue technology, which is applied in the field of medicine and can solve the problems of addiction and restriction of anti-fatigue drugs

Active Publication Date: 2017-12-22
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently clinical anti-fatigue drugs are strictly restricted due to adverse reactions such as side effects, addiction, and excitability

Method used

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  • Application of kinsenoside to preparation of anti-fatigue medicine
  • Application of kinsenoside to preparation of anti-fatigue medicine
  • Application of kinsenoside to preparation of anti-fatigue medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1: the preparation of aureoside

[0027] (1) Preparation of extracting solution: after crushing the herbal medicinal materials of the genus Lemonia genus and its close relatives, put them into an extraction tank, and heat extract with 40-90% ethanol for 2-3 times, and the amount of each solvent is about 8% of the crude drug amount. ~10 times, each extraction time is 1-2 hours, and the extracts are combined;

[0028] (2) Refining, concentrating and drying: Concentrating the above extract, extracting the concentrate with ethyl acetate to remove impurities, concentrating and drying the water layer to obtain a crude extract;

[0029] (3) Separation and purification: Dissolve the above crude extract in water and load it on a macroporous adsorption resin, collect the eluted part with 0-10% ethanol, concentrate and dry to obtain the crude product of auroside, load it on a forward silica gel column, and use two Chloromethane-methanol system elution, collect 6:1 elut...

Embodiment 2

[0030] Embodiment 2: anti-fatigue pharmacodynamic experiment of auroside

[0031] 2.1 Experimental materials

[0032] 18-22g ICR mice (provided by the Experimental Animal Center of Second Military Medical University) 20, mouse LDH (lactate dehydrogenase) and BLA (blood lactic acid) kit (Nanjing Jiancheng Bioengineering Institute). Main instruments: 5L beaker (Shanghai Heqi Glass Instrument Co., Ltd.), microplate reader (BIO-RAD 550), centrifuge (Labofuge 400R, Heraeus Company), electronic balance (FA110A type, Shanghai Precision Scientific Instrument Co., Ltd.).

[0033] 2.2 Animal grouping and experimental treatment

[0034] Before the experiment, 20 mice were weighed and randomly divided into 2 groups according to body weight, 10 mice in each group, free to eat and drink, and to drink water. Divided into blank group and auroglucoside group. Blank group: give the same volume of normal saline as the administration group; auroglutin group: intragastric administration, once a...

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Abstract

The invention relates to the technical field of medicine, in particular to application of kinsenoside to preparation of anti-fatigue medicine or food. The invention provides a novel medicine purpose of the kinsenoside. Through being proved by pharmacodynamics study, the kinsenoside can obviously prolong the mice loaded swimming time; the anti-fatigue effect is obvious; and the kinsenoside can be used for preparing the anti-fatigue medicine or food. The invention provides a novel source for developing novel anti-fatigue medicine.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to the application of auroside prepared from plants of the genus Schima and its close relatives in anti-fatigue medicine or food. Background technique [0002] Fatigue is a physiological and psychological phenomenon, which is caused by excessive mental and physical activity, mental stimulation and other factors. Generally, it can be divided into two types: peripheral fatigue and central fatigue. With the development of the economy and the acceleration of the pace of life, long hours of work without effective sleep or irregular life lead to more and more people feeling tired, muscle pain, lack of concentration, memory loss, depression, Sleep disorders, etc. These symptoms are generally diagnosed as fatigue clinically, covering peripheral and central fatigue. Peripheral fatigue is more common in physical workers, and central fatigue is more common in mental workers. Fatigue, espe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P37/00A23L33/105
CPCA23V2002/00A61K31/7048A23L33/105A23V2200/30A23V2250/21
Inventor 郑承剑吴岩斌吴锦忠秦路平黄泽豪郭耀丽韩婷辛海量
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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