Skin pharmaceutical composition taking mometasone furoate as active component

A technology of mometasone furoate and active ingredients, applied in the direction of drug combination, organic active ingredients, anhydride/acid/halide active ingredients, etc., can solve problems such as pigmentation, skin atrophy and thinning, and telangiectasia

Inactive Publication Date: 2017-12-29
TIANJIN JINYAO GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

While glucocorticoids have a strong curative effect, there are also adverse reactions such as skin atrophy and thinning, telangiectasia, pigmentation, and secondary infection

Method used

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  • Skin pharmaceutical composition taking mometasone furoate as active component
  • Skin pharmaceutical composition taking mometasone furoate as active component
  • Skin pharmaceutical composition taking mometasone furoate as active component

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Embodiment 1 suspension

[0050] Active ingredient list

[0051]

[0052] Adjuvant prescription and preparation method of embodiment 1

[0053] Appropriate amount of sodium chloride, sodium carboxymethylcellulose 2.5g, poloxamer 0.5g, add distilled water to 1000g

[0054] Preparation method: Dissolve the prescribed amount of sodium carboxymethylcellulose and poloxamer in 500ml of water for injection, stir to dissolve, add the prescribed amount of azulene sulfonic acid compounds; then add the prescribed amount of mometasone furoate, add The rest of the water for injection. Adjust to isotonicity with sodium chloride and dispense.

Embodiment 1

[0056] According to the adjuvant prescription and preparation method in Example 1, prepare azulene sulfonic acid compound suspension and glucocorticoid drug suspension respectively, the number of comparative example 1 corresponds to the number of Example 1, according to the activity used The components are different, and the end number of the comparative examples is increased by G (glucocorticoid drugs) or Y (azulene sulfonic acid compounds). For example, the active ingredients of Example 1-1 are G1 (1g) and Y1 (1g), while the active ingredients of Comparative Example 1-1-G are glucocorticoids (no azulene sulfonic acid drugs), and the active ingredients are G1 (1 g), the active ingredient of the suspension 1-1-Y of the comparative example is azulene sulfonic acid drugs (no glucocorticoid drugs), and the active ingredient is Y1 (1 g).

Embodiment 2

[0057] Embodiment 2 gel

[0058] Active ingredient list

[0059]

[0060] Adjuvant prescription and preparation method of embodiment 2

[0061] See the above table for the dosage of active ingredients glucocorticoids and azulene sulfonic acids

[0062] Polyethylene glycol 600-100g, propylene glycol 100g, absolute ethanol 100g, carbomer 93430g, appropriate amount of triethanolamine, add distilled water to 1000g.

[0063] Preparation method: Sprinkle Carbomer 934 evenly on the surface of 300ml distilled water, let it stand still to make it fully swell; mix the prescribed amount of glucocorticoids and azulene sulfonic acid drugs with absolute ethanol, and then add Prescription measures of water, macrogol 600, and propylene glycol. Mix and stir the above components, slowly add triethanolamine dropwise, stir while adding, control pH 6.0-7.0, and then pack it separately.

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PUM

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Abstract

The invention relates to a pharmaceutical composition which is prepared from an active component and drug auxiliary materials and is directly acted on skin. The pharmaceutical composition is characterized in that the active component contains one of mometasone furoate and azulene sulfonic acid or salt thereof.

Description

technical field [0001] The invention relates to a pharmaceutical composition directly acting on the skin composed of active components and pharmaceutical auxiliary materials, characterized in that the active components contain one of glucocorticoids and one of azulenesulfonic acid or its salts. Background technique [0002] Glucocorticoids are a type of steroidal corticosteroids. They have a steroidal compound structure and can inhibit inflammation and allergic skin reactions. At the same time, they can also inhibit reactions associated with accelerated cell regeneration and cause symptoms such as erythema, edema, and thick skin. Thinning, reduction of surface roughness of the skin, and relief of itching, burning, and pain. Since ester groups are introduced into these compounds, especially at the 21 and / or 17 positions of the pregnant compounds, their fat solubility is better, so that better curative effect can be achieved in external treatment. Corticosteroids include hydr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/58A61K31/185A61P29/00A61P17/04A61P17/06A61P17/00
CPCA61K31/185A61K31/58A61K2300/00
Inventor 孙亮
Owner TIANJIN JINYAO GRP
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