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Ambient ionization mass spectrometry imaging platform for direct mapping from bulk tissue

A tissue and in situ technique, applied in the field of mass spectrometry, can solve problems such as uncertainty and spectral data that cannot be studied

Inactive Publication Date: 2018-01-02
MICROMASS UK LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although conventional workflows provide satisfactory data, there is a degree of uncertainty involved in the validation step as the tissue portion that produces the spectral data is vaporized during analysis and cannot be studied

Method used

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  • Ambient ionization mass spectrometry imaging platform for direct mapping from bulk tissue
  • Ambient ionization mass spectrometry imaging platform for direct mapping from bulk tissue
  • Ambient ionization mass spectrometry imaging platform for direct mapping from bulk tissue

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Embodiment Construction

[0192] Various embodiments will now be described in more detail below, which generally relate to ion imagers with in situ ionizing ion source arrangements.

[0193] The device is used to automatically sample a plurality of different locations on the sample and obtain mass spectral data and / or ion mobility data corresponding to each location. The obtained mass spectral data and / or ion mobility data are then used to build, train or improve a sample classification model.

[0194] in situ ionization ion source

[0195] According to various embodiments, the first device is arranged and adapted to generate an aerosol, smoke or vapor from a sample (eg tissue in vivo). The device may include an in situ ionizing ion source characterized by the ability to generate analyte aerosols, fumes or vapors from native or unmodified samples. For example, other types of ionization ion sources, such as matrix-assisted laser desorption ionization ("MALDI") ion sources, require the addition of ma...

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Abstract

A method of ion imaging is disclosed that includes automatically sampling a plurality of different locations on a sample (20) using a first device (21) which is arranged and adapted to generate aerosol, smoke or vapour from the sample (20). Mass spectral data and / or ion mobility data corresponding to each location is obtained and the obtained mass spectral data and / or ion mobility data is used toconstruct, train or improve a sample classification model.

Description

[0001] Cross References to Related Applications [0002] This application claims UK Patent Application No. 1503876.3 filed March 6, 2015, UK Patent Application No. 1503864.9 filed March 6, 2015, UK Patent Application No. 1518369.2 filed October 16, 2015, 2015 UK Patent Application No. 1503877.1 filed March 6, UK Patent Application No. 1503867.2 filed March 6, 2015, UK Patent Application No. 1503863.1 filed March 6, 2015, filed March 6, 2015 UK Patent Application No. 1503878.9, UK Patent Application No. 1503879.7 filed 6 March 2015 and UK Patent Application No. 1516003.9 filed 9 September 2015. The entire contents of these applications are incorporated herein by reference. technical field [0003] The present invention relates generally to mass spectrometry and, in particular, to ion imaging methods, electrosurgical methods, ion imagers, mass spectrometers and electrosurgical devices. Various embodiments are contemplated wherein the analyte ions generated by the in situ ioniz...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/62H01J49/00H01J49/04H01J49/06H01J49/16
CPCA61B10/0233A61B10/0283A61B17/320068A61B18/14A61B18/20A61B2218/008G01N33/6848H01J49/0036H01J49/0404H01J49/044H01J49/0459H01J49/068H01J49/16A61B10/00A61B10/0041A61B2010/0083G01N33/92H01J49/049H01J49/0463G16B40/10G16B40/20G16B40/30G01N33/50H01J49/0004G01N27/623G16B20/00A61B18/00G01N3/00G01N9/00A61B90/13A61B2017/320069G16H10/40G16H15/00G16H50/20A61B1/00013A61B1/041A61B1/2736A61B1/31A61B5/0066A61B5/0075A61B5/015A61B5/0507A61B5/055A61B5/14542A61B6/032A61B6/037A61B8/13A61B17/00A61B18/04A61B18/042A61B18/1445A61B18/1815A61B2018/00577A61B2018/00589A61B2018/00994A61B2218/002A61F13/38C12Q1/025C12Q1/04C12Q1/18C12Q1/24G01N1/2202G01N27/624G01N30/724G01N33/487G01N33/48735G01N33/6851G01N2001/2223G01N2333/195G01N2405/00G01N2405/04G01N2405/08G01N2570/00G01N2800/26H01J49/0027H01J49/0031H01J49/025H01J49/0409H01J49/0422H01J49/0445H01J49/0468H01J49/061H01J49/10H01J49/14H01J49/164H01J49/24H01J49/26
Inventor 埃姆里斯·琼斯史蒂文·德里克·普林格尔佐尔坦·塔卡茨
Owner MICROMASS UK LTD
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