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A perampanel dry suspension and a preparing method thereof

A technology for dry and dry suspensions of perampanel, which is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, organic active ingredients, etc., can solve the problems of inconvenient portability of oral suspensions and reduced patient compliance. , to achieve the effect of improving bioavailability and solubility

Inactive Publication Date: 2018-01-05
ZHEJIANG POLY PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, considering the inconvenience of carrying the oral suspension, the way of administration leads to a decrease in patient compliance, and the storage stability of the drug, we plan to develop a dry suspension to solve the above problems

Method used

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  • A perampanel dry suspension and a preparing method thereof
  • A perampanel dry suspension and a preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1: Preparation of perampanel dry suspension 1000g, prepared using the following materials:

[0026] Perampanel 4g Povidone K30 150g Mannitol 824g Xanthan Gum 10g

[0027] Micronized Silica Gel 5g Titanium Dioxide 3g Sucralose 3g Orange Flavor 1g

[0028] And adopt following preparation method to prepare:

[0029] (1) Preparation of perampanel solid dispersion: firstly mix perampanel and povidone k30 uniformly, then add them into a hot-melt extruder to prepare perampanel solid dispersion;

[0030] (2) The perampanel solid dispersion is pulverized and sieved, mixed with mannitol, xanthan gum, micropowdered silica gel, titanium dioxide, sucralose and orange essence to obtain the product.

Embodiment 2

[0031] Embodiment 2: Preparation of perampanel dry suspension 1000g, prepared using the following materials:

[0032] Perampanel 10g Copovidone 350g Microcrystalline Cellulose 623g Carmellose Sodium 10g

[0033] Micronized silica gel 2g titanium dioxide 2g lactose 2g orange essence 1g.

[0034] The preparation method is the same as the examples.

Embodiment 3

[0035] Embodiment 3: Preparation of perampanel dry suspension 1000g, prepared using the following materials:

[0036] Perampanel 2g Hypromellose 100g Mannitol 867g Sodium Alginate 10g

[0037] Micronized Silica Gel 10g Titanium Dioxide 8g Sucralose 2g Cherry Flavor 1g

[0038] The preparation method is the same as in Example 1.

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Abstract

The invention relates to a perampanel dry suspension and a preparing method thereof. According to the perampanel dry suspension, a medicine active component that is perampanel and a carrier matrix areprepared into a perampanel solid dispersion. The perampanel dry suspension is prepared from 0.2-1% of perampanel, 20-40% of the carrier matrix, 60-80% of a filler, 0.2-2% of a suspending aid, 0.1-1%of a glidant, 0.2-2% of a corrective and 0.1-1% of an opacifying agent, wherein the perampanel and the carrier matrix are prepared into the perampanel solid dispersion firstly and then the solid dispersion is mixed with other auxiliary materials. The perampanel solid dispersion is prepared by utilizing a solid dispersion technique, and is further prepared into the perampanel dry suspension, thus achieving the objective of increasing solubility and bioavailability of the perampanel. In addition, the dry suspension can overcome problems that administration of tablets is difficult, and oral suspensions are inconvenient to carry and trouble in administration, and the like.

Description

technical field [0001] The invention relates to a medicine for treating epilepsy, in particular to perampanel dry suspension and a preparation method thereof. Background technique [0002] Epilepsy is a chronic disease with recurrent seizures, protracted course, and sudden brain dysfunction. It is clinically manifested as symptoms of motor, sensory, consciousness, and autonomic dysfunction. As the second largest disease in neurology after cerebrovascular disease, it seriously threatens human health. According to the statistics of the World Health Organization (WHO), there are about 50 million people in the world who are suffering from epilepsy, 80% of whom are in developing countries. At the same time, another 2 million people suffer from epilepsy every year. There are about 9 million epilepsy patients in my country, and the incidence of epilepsy is about 7‰, about 40% of them have never received any treatment, and nearly 40% of them have received informal treatment. Antie...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/444A61P25/08
Inventor 范敏华
Owner ZHEJIANG POLY PHARMA
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