A perampanel dry suspension and a preparing method thereof
A technology for dry and dry suspensions of perampanel, which is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, organic active ingredients, etc., can solve the problems of inconvenient portability of oral suspensions and reduced patient compliance. , to achieve the effect of improving bioavailability and solubility
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Embodiment 1
[0025] Embodiment 1: Preparation of perampanel dry suspension 1000g, prepared using the following materials:
[0026] Perampanel 4g Povidone K30 150g Mannitol 824g Xanthan Gum 10g
[0027] Micronized Silica Gel 5g Titanium Dioxide 3g Sucralose 3g Orange Flavor 1g
[0028] And adopt following preparation method to prepare:
[0029] (1) Preparation of perampanel solid dispersion: firstly mix perampanel and povidone k30 uniformly, then add them into a hot-melt extruder to prepare perampanel solid dispersion;
[0030] (2) The perampanel solid dispersion is pulverized and sieved, mixed with mannitol, xanthan gum, micropowdered silica gel, titanium dioxide, sucralose and orange essence to obtain the product.
Embodiment 2
[0031] Embodiment 2: Preparation of perampanel dry suspension 1000g, prepared using the following materials:
[0032] Perampanel 10g Copovidone 350g Microcrystalline Cellulose 623g Carmellose Sodium 10g
[0033] Micronized silica gel 2g titanium dioxide 2g lactose 2g orange essence 1g.
[0034] The preparation method is the same as the examples.
Embodiment 3
[0035] Embodiment 3: Preparation of perampanel dry suspension 1000g, prepared using the following materials:
[0036] Perampanel 2g Hypromellose 100g Mannitol 867g Sodium Alginate 10g
[0037] Micronized Silica Gel 10g Titanium Dioxide 8g Sucralose 2g Cherry Flavor 1g
[0038] The preparation method is the same as in Example 1.
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