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Application of TRIM31 inhibitor magnetic targeting drug-loaded microspheres in preparation of drugs for inhibiting proliferation ability of PDAC

A technology of drug-loaded microspheres and proliferation ability, applied in the field of pharmacy, can solve the problems of less TRIM31, unclear effect, and unreported effect of pancreatic ductal adenocarcinoma.

Inactive Publication Date: 2018-01-16
孙诚谊
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are few studies on TRIM31, and its role in tumorigenesis and progression is still unclear, and its role in pancreatic ductal adenocarcinoma has not been reported yet

Method used

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  • Application of TRIM31 inhibitor magnetic targeting drug-loaded microspheres in preparation of drugs for inhibiting proliferation ability of PDAC
  • Application of TRIM31 inhibitor magnetic targeting drug-loaded microspheres in preparation of drugs for inhibiting proliferation ability of PDAC
  • Application of TRIM31 inhibitor magnetic targeting drug-loaded microspheres in preparation of drugs for inhibiting proliferation ability of PDAC

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0044] Embodiment of the invention

[0045] Mix and stir an appropriate amount of PEG4000, TRIM31 inhibitor aqueous solution, magnetic fluid, and albumin, dissolve and mix, add and mix with 100ml of castor oil containing surfactant Span80, mix for 10min, fully emulsify, take castor oil 100II11 and heat to 160°C, Add the above emulsion, keep warm at 60°C for 10min, then stir at room temperature for 6h at a constant speed. Add ether 200r Ill to degrease, centrifuge, remove the oil phase, rinse the starch with ether and ethanol in turn, replace it in distilled water, and freeze-dry for 48h.

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Abstract

The invention discloses an application of TRIM31 inhibitor magnetic targeting drug-loaded microspheres in preparation of drugs for inhibiting the proliferation ability of PDAC. With the correlation between TRIM31 and the proliferation of the pancreatic ductal adenocarcinoma cell, the TRIM31 inhibitor magnetic drug-loaded microspheres as effective ingredients are made into the drugs, and the drugshave a significant inhibitory effect on the proliferation of the pancreatic ductal adenocarcinoma cell.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to the application of TRIM31 inhibitor magnetic targeting drug-loaded microspheres in the preparation of drugs for inhibiting the proliferation of PDAC. Background technique [0002] Pancreatic ductal adenocarcinoma is a highly malignant tumor of the digestive tract. In recent years, the global incidence has been increasing year by year, but the mortality rate has remained high. The 5-year survival rate is only 3%-6%. The poor prognosis of pancreatic ductal adenocarcinoma is due to the late appearance of clinical symptoms. Most patients lose the chance of surgery once diagnosed, and the only chance for patients with pancreatic ductal adenocarcinoma to obtain a long survival rate is to be able to undergo radical surgical resection. . Therefore, early accurate diagnosis and new treatment methods are particularly important for the diagnosis and treatment of pancreatic ductal adenocarcinoma. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K45/00A61K41/00A61P35/00
Inventor 孙诚谊张宏潘耀振陈玲张浩田舍何志伟
Owner 孙诚谊
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