Compound preparation for treating rejection reaction after organ transplanting

A compound preparation and rejection technology, applied in the field of biopharmaceuticals, can solve the problems of inducing lymphoma and malignant tumors, and achieve the effect of improving the safety of medication and reducing the risk of infection

Inactive Publication Date: 2018-01-16
WUXI FORTUNE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, in the prior art, mycophenolate mofetil is simply used as a treatment for patients receiving immunosuppressant therapy after organ transplantation. Long-term use of drugs containing only mycophenolate mofetil as an active ingredient may induce lymphoma, Risk of Skin Cancer and Other Malignancies

Method used

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  • Compound preparation for treating rejection reaction after organ transplanting
  • Compound preparation for treating rejection reaction after organ transplanting
  • Compound preparation for treating rejection reaction after organ transplanting

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020]

[0021] In the present embodiment, the preparation method of this compound preparation comprises the following steps:

[0022] Step (1), weighing the raw and auxiliary materials of the above-mentioned prescription amount, passing through a 45-mesh sieve respectively for subsequent use.

[0023] Step (2), putting the sieved raw and auxiliary materials into a wet granulator, premixing, spraying an appropriate amount of purified water to granulate, drying, and sizing.

[0024] Step (3), adding the granulated material into the mixer, adding lubricant, and mixing evenly.

[0025] Step (4), using No. 1 capsule mold on the capsule filling machine to prepare the blended material and hollow gelatin capsules into drug-containing capsules.

Embodiment 2

[0027]

[0028] In the present embodiment, the preparation method of this compound preparation comprises the following steps:

[0029] Step (1), weighing the raw and auxiliary materials of the above-mentioned prescription amount, passing through a 60-mesh sieve respectively for subsequent use.

[0030] Step (2), putting the sieved raw and auxiliary materials into a wet granulator, premixing, spraying an appropriate amount of purified water to granulate, drying, and sizing.

[0031] Step (3), adding the granulated material into the mixer, adding lubricant, and mixing evenly.

[0032] Step (4), using No. 1 capsule mold on the capsule filling machine to prepare the blended material and hollow gelatin capsules into drug-containing capsules.

Embodiment 3

[0034]

[0035] In the present embodiment, the preparation method of this compound preparation comprises the following steps:

[0036] Step (1), weighing the raw and auxiliary materials of the above-mentioned prescription amount, passing through a 70-mesh sieve respectively for subsequent use.

[0037] Step (2), putting the sieved raw and auxiliary materials into a wet granulator, premixing, spraying an appropriate amount of purified water to granulate, drying, and sizing.

[0038] Step (3), adding the granulated material into the mixer, adding lubricant, and mixing evenly.

[0039] Step (4), using No. 1 capsule mold on the capsule filling machine to prepare the blended material and hollow gelatin capsules into capsules containing the compound preparation.

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Abstract

The invention provides a compound preparation for treating rejection reaction after organ transplanting. The compound preparation is prepared from the following components in parts by weight: 50 to 85parts of mycophenolate mofetil, 3 to 6 parts of radix angelicae sinensis, 3 to 6 parts of cordyceps, 8 to 20 parts of filling agent, 3 to 8 parts of adhesive, 2 to 10 parts of disintegrating agent, and 0.5 to 2 parts of lubricant. The compound preparation for treating the rejection reaction after organ transplanting has the advantages that the infection risk after operation is obviously decreased; more importantly, the inducing risk of lymph cancers, skin cancers and other malicious tumors due to taking of immunity inhibitors which takes the mycophenolate mofetil as the main component for a long time can be obviously decreased, so that the safety in medicine taking is improved.

Description

technical field [0001] The invention relates to the technical field of biopharmaceuticals, in particular to a compound preparation for treating rejection after organ transplantation. Background technique [0002] After the recipient undergoes allogeneic tissue or organ transplantation, the foreign tissue or organ is recognized as a "foreign component" by the recipient's immune system, which initiates an immunological response to attack, destroy and eliminate the graft . Although there are many drugs currently used clinically to treat transplant rejection, due to the effect of immunosuppression, these drugs can increase the chance of infection, and can also cause diseases such as lymphoma, skin cancer and malignant tumors. [0003] Mycophenolate mofetil (MMF) is a new type of antimetabolite immunosuppressant, which acts by deesterification in the body into the active ingredient of mycophenolic acid (MPA). Mycophenolate mofetil is indicated for the prevention of organ reject...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/232A61K9/48A61P37/06A61K31/5377
Inventor 郁晨燕秦玉荣韩小霜李标有
Owner WUXI FORTUNE PHARMA
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