Preparation method of film coating agent for miconazole nitrate
A technology of miconazole nitrate and film coating agent is applied in the directions of medical preparations containing active ingredients, antifungal agents, pharmaceutical formulations, etc., and achieves the effects of good mechanical properties, no need for bandaging, and superior curative effect.
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Embodiment 1
[0019] A kind of preparation method for the coating agent of miconazole nitrate of the present embodiment, comprises the following steps:
[0020] (1) Add 20g of miconazole nitrate and 10g of terbinafine hydrochloride into 250g of ethanol, stir to dissolve, and obtain a mixed solution for use;
[0021] (2) Sprinkle 4g of chitosan evenly to make it swell naturally;
[0022] (3) Add 1.0g of laurocaprazine, stir constantly, and add ethanol to 1000mL;
[0023] (4) Adjust the pH to 6.0~7.0 and stir well to obtain the coating agent for miconazole nitrate.
[0024] The specific implementation process is to clean the affected area, apply the prepared coating agent for miconazole nitrate evenly on the surface of the affected area, and after it dries naturally, a gel-like film with a thickness of 1 to 3 mm will be formed. After 3 to 5 hours, After the drug administration in the film is completed, tear it off from the surface of the affected area, apply new drugs, 1-2 times a day, wh...
Embodiment 2
[0026] In this embodiment, on the basis of the above embodiments, the stirring process of the step (1) is further defined, which is mainly completed by a magnetic stirrer. The magnetic stirrer utilizes the characteristic of homosexual repulsion of magnetic substances to drive the magnetic stirrer to rotate by constantly changing the polarity of the two ends of the base, and the rotation of the magnetic stirrer drives the sample to rotate, so that the medicine is evenly mixed; the magnetic stirrer adopts high-quality DC The motor has low noise and stable speed regulation; the fully enclosed heating plate can be used for auxiliary heating and can be used for long-term heating; the stirring bar made of PTFE and high-quality magnetic steel is resistant to high temperature, wear and chemical Corrosion and strong magnetism; it can be mixed in a closed container, which is ideal and convenient to use; the temperature and temperature display of the agitator can be set and used for long-...
Embodiment 3
[0028] In this embodiment, on the basis of the above embodiments, the mixing container for the mixed solution in the step (3) is further defined as a 1200ml large beaker. Other steps in this embodiment are the same as those in the above embodiment, and will not be repeated here.
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