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Blood dialysis solution

A technology of hemodialysis and dialysate, which is applied in the medical field, can solve the problems of patient balance and poor anticoagulation effect, and achieve the effect of reducing the risk of bleeding and improving the effect of anticoagulation

Inactive Publication Date: 2018-02-13
宋宏婷
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current anticoagulation effect of dialysate is not good, and it is difficult to achieve a balance between bleeding and coagulation in vitro

Method used

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Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment 1

[0020] Specific embodiment 1: a hemodialysate, characterized in that it includes chloride ions, sodium ions, potassium ions, magnesium ions, citrate ions, glucose, calcium ions and 4,6-dichloro-5-nitro-2 - Propylthiopyrimidine, and 0.2-5% w / v pirfenidone, hydrogen acetate ions and bicarbonate particles.

[0021] In a preferred implementation, the concentration of pirfenidone is 0.2% w / v, sodium chloride is 10% w / v, calcium chloride is 0.2% w / v, potassium chloride is 2% w / v, glucose It is 5% W / V, citric acid 0.1% W / V, 4,6-dichloro-5-nitro-2-propylthiopyrimidine 3% W / V, and the pH is adjusted to between 7.2-7.3.

[0022] In another preferred embodiment, the concentration of each substance is 15% W / V for sodium chloride, 5% W / V for calcium chloride, 5% W / V for potassium chloride, and 10% W / V for glucose , Citric acid 2% w / v, 4,6-dichloro-5-nitro-2-propylthiopyrimidine 5% w / v and pirfenidone 5% w / v, while pH was adjusted to 7.2- between 7.3.

[0023] The configuration method of...

specific Embodiment 2

[0029] Specific embodiment 2: a configuration method of hemodialysate, the steps are as follows:

[0030] Step 1. Repeat the dialysate cartridge with reverse osmosis water, sterilize it with alcohol, and rinse it for later use;

[0031] Step 2, according to the concentration of pirfenidone is 0.2%W / V, sodium chloride is 10%W / V, calcium chloride is 0.2%W / V, potassium chloride is 2%W / V, glucose is 5% % W / V, citric acid 0.1%W / V, 4,6-dichloro-5-nitro-2-propylthiopyrimidine 3%W / V ratio, add raw materials, dissolve, adjust pH value to 7.2-7.3 .

[0032] Step 3, adjust the pH concentration of dialysate;

[0033] Step 4. Save.

[0034] In this example, the pH value should be adjusted to between 7.2-7.3 to have a better anticoagulant effect.

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PUM

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Abstract

The invention discloses a blood dialysis solution, and belongs to the field of medical treatment. The blood dialysis solution comprises chloride ions, sodium ions, potassium ions, magnesium ions, citrate ions, glucose, calcium ions, 4,6-dichloro-5-nitryl-2-propylthiouracil, 0.2-5% W / V of pirfenidone, hydrogenacetate ions and bicarbonate particles.

Description

technical field [0001] The invention relates to the medical field, in particular to a hemodialysis fluid. Background technique [0002] Dialysis is a separation and purification technology that separates small molecules from biological macromolecules through the principle of small molecules diffusing into water (or buffer) through a semipermeable membrane. Dialysis therapy is a treatment method in which components (solutes or water) in body fluids are excreted from the body through a semipermeable membrane. Generally, it can be divided into two types: hemodialysis and peritoneal dialysis. [0003] Hemodialysis (HD) is one of the methods of renal replacement therapy for patients with acute and chronic renal failure. It drains the blood from the body to the outside of the body, through a dialyzer composed of numerous hollow fibers, the blood and the electrolyte solution (dialysate) with a similar concentration of the body are exchanged inside and outside the hollow fibers thr...

Claims

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Application Information

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IPC IPC(8): A61K33/14A61P7/08A61K33/06A61K31/7004A61K31/194A61K31/4418A61K31/505
CPCA61K33/14A61K31/194A61K31/4418A61K31/505A61K31/7004A61K33/06A61K2300/00
Inventor 宋宏婷
Owner 宋宏婷
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