Artificial nasolacrimal duct and preparation method thereof

A nasolacrimal duct, artificial technology, used in medical science, prosthesis, stents, etc., can solve the problems of obvious foreign body sensation, affect the curative effect, high incidence of shedding, achieve good biocompatibility and stability, not easy to reject and inflammatory response, simple and feasible effect of preparation method

Active Publication Date: 2018-02-16
广州锐澄医疗技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These materials have the following defects: (1) metal materials: mostly made of alloys, with good supporting effect, but high hardness, not easy to bend and deform, high lumen blockage rate, and many complications, which are rarely used at present; (2) glass (3) Medical silicone rubber: stable physical and chemical properties, non-toxic, and no rejection; but because the silicone is soft, it is easy to be squeezed and narrowed by the congenitally small nasolacrimal duct. Affect the curative effect; (4) Polyurethane: Mode

Method used

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  • Artificial nasolacrimal duct and preparation method thereof
  • Artificial nasolacrimal duct and preparation method thereof
  • Artificial nasolacrimal duct and preparation method thereof

Examples

Experimental program
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Embodiment 1

[0027] An embodiment of the artificial nasolacrimal duct of the present invention comprises the following preparation raw materials in parts by weight: 40 parts of hydroxyethyl methacrylate, 20 parts of crosslinking agent, 40 parts of water, 5 parts of thermal initiator and 10 parts of catalyst;

[0028] Wherein, the crosslinking agent is polyethylene glycol diacrylate, the thermal initiator is azobisisobutyronitrile, and the catalyst is N,N,N',N'-tetramethylethylenediamine.

[0029] A kind of artificial nasolacrimal duct prepared by adopting the preparation raw materials of artificial nasolacrimal duct described in the present embodiment, the preparation method of described artificial nasolacrimal duct comprises the following steps:

[0030] (1), mix hydroxyethyl methacrylate, cross-linking agent, water, initiator and catalyst evenly, inject artificial nasolacrimal duct mold;

[0031] (2), the artificial nasolacrimal duct mold containing artificial nasolacrimal duct preparati...

Embodiment 2

[0034] An embodiment of the artificial nasolacrimal duct of the present invention, the difference between the artificial nasolacrimal duct described in this embodiment and embodiment 1 is that the ratio of the thermal initiator and the catalyst is different, the artificial nasolacrimal duct described in this embodiment The preparation raw materials comprising the following parts by weight: 40 parts of hydroxyethyl methacrylate, 20 parts of crosslinking agent, 40 parts of water, 5 parts of thermal initiator and 5 parts of catalyst;

[0035] Wherein, the crosslinking agent is polyethylene glycol diacrylate, the thermal initiator is azobisisobutyronitrile, and the catalyst is N,N,N',N'-tetramethylethylenediamine.

[0036] The preparation method of the artificial nasolacrimal duct described in this example is the same as that in Example 1.

Embodiment 3

[0038] An embodiment of the artificial nasolacrimal duct of the present invention, the difference between the artificial nasolacrimal duct described in this embodiment and embodiment 1 is that the ratio of the thermal initiator and the catalyst is different, the artificial nasolacrimal duct described in this embodiment Contains the following preparation raw materials in parts by weight: 40 parts of hydroxyethyl methacrylate, 20 parts of crosslinking agent, 40 parts of water, 5 parts of thermal initiator and 15 parts of catalyst;

[0039] Wherein, the crosslinking agent is polyethylene glycol diacrylate, the thermal initiator is azobisisobutyronitrile, and the catalyst is N,N,N',N'-tetramethylethylenediamine.

[0040] The preparation method of the artificial nasolacrimal duct described in this example is the same as that in Example 1.

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PUM

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Abstract

The invention discloses an artificial nasolacrimal duct. The artificial nasolacrimal duct comprises the following preparation raw materials in parts by weight: 10 to 80 parts of hydroxyethyl methylacrylate, 1 to 20 parts of a crosslinking agent, 10 to 80 parts of water and 0.042 to 36 parts of a reaction initiator, wherein the crosslinking agent is at least one of polyethylene glycol diacrylate, ethylene glycol dimethacrylate and triallyl isocyanurate; the reaction initiator is a mixture of a thermal initiator and a catalyst or a photoinitiator. The invention further provides a preparation method of the artificial nasolacrimal duct. The artificial nasolacrimal duct has relatively high tear guide efficiency, high biocompatibility and high stability, can obtain longer implantation cycle, andis not liable to cause rejection or inflammatory reaction during long-time implantation; the artificial nasolacrimal duct can be expanded when absorbing water, and achieves a self-fixing effect; theimplantation mode is simple and the operation is facilitated.

Description

technical field [0001] The invention relates to a polymer material, in particular to an artificial nasolacrimal duct and a preparation method thereof. Background technique [0002] The nasolacrimal ducts are two ducts that discharge tears from the eyes into the nasal cavity. The one located in the bony official cavity is called the inner bone, which is about 12.4mm, and the one located in the mucosa of the outer wall of the nasal cavity is called the inner nasal cavity, which is about 5.32mm long. Epiphora is a common and relatively common eye disease. It is a frequently-occurring disease caused by tear fluid stagnation in the lacrimal sac due to stenosis or blockage of the nasolacrimal duct. Patients with this disease will cry for a long time, which seriously affects the quality of life of the patient. At present, the traditional treatment methods for such diseases are mainly lacrimal duct probing and dacryocystorhinostomy, but this type of operation is not only complicated...

Claims

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Application Information

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IPC IPC(8): C08F290/06C08F220/20C08F2/48C08F226/06C08F222/14A61F2/86
CPCA61F2/86A61F2210/0061A61F2240/001C08F2/48C08F220/20C08F290/062C08F222/102
Inventor 李锐聪杨习锋曾晨光
Owner 广州锐澄医疗技术有限公司
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