Artificial nasolacrimal duct and preparation method thereof

Abstract

The invention discloses hydrogel. The hydrogel is prepared from the following preparation raw materials in parts by weight: 10 to 80 parts of hydroxyethyl methacrylate, 1 to 40 parts of glycerol, 1 to20 parts of a crosslinking agent, 10 to 40 parts of water and 0.013 to 36 parts of an initiator, wherein the crosslinking agent is at least one of polyethylene glycol diacrylate, ethylene glycol dimethacrylate and triallyl isocyanurate. The hydrogel disclosed by the invention has good hydrophilic performance and relatively strong mechanical properties, and has relatively good biocompatibility andstability in human bodies. The invention further provides an artificial nasolacrimal duct containing the hydrogel disclosed by the invention. The artificial nasolacrimal duct prepared from the hydrogel disclosed by the invention has relatively high tear guiding efficiency and relatively good biocompatibility and stability; a longer implanting period can be obtained and rejection and inflammatoryresponses are not easily caused after the artificial nasolacrimal duct is implanted for a long period; the artificial nasolacrimal duct can be expanded after absorbing water and a self-fixing effect can be realized; an implanting manner is simple and easy to operate.

Description

technical field [0001] The invention relates to a polymer material, in particular to an artificial nasolacrimal duct and a preparation method thereof. Background technique [0002] The nasolacrimal ducts are two ducts that discharge tears from the eyes into the nasal cavity. The one located in the bony official cavity is called the inner bone, which is about 12.4mm, and the one located in the mucosa of the outer wall of the nasal cavity is called the inner nasal cavity, which is about 5.32mm long. Epiphora is a common and relatively common eye disease. It is a frequently-occurring disease caused by tear fluid stagnation in the lacrimal sac due to stenosis or blockage of the nasolacrimal duct. Patients with this disease will cry for a long time, which seriously affects the quality of life of the patient. At present, the traditional treatment methods for such diseases are mainly lacrimal duct probing and dacryocystorhinostomy, but this type of operation is not only complicated...

AI Technical Summary

Problems solved by technology

These materials have the following defects: (1) metal materials: mostly made of alloys, with good supporting effect, but high hardness, not easy to bend and deform, high lumen blockage rate, and many complications, which are rarely used at present; (2) glass (3) Medical silicone rubber: stable physical and chemical properties, non-toxic, and no rejection; but because the silicone is soft, it is easy to be squeezed and narrowed by the congenitally small nasolacrimal duct. Affect the curative effect; (4) Polyurethane: Moderate hardness has better supporting effect, but poor biocompatibility, long-term placement can easily induce body rejection and chronic inflammation

This often causes secondary damage, leading to reactions such as bleeding and inflammation, and then granulation hyperplasia and other phenomena, resulting in re-occlusion of the lacrimal duct

In addition, these stents are usually fixed by using the end size larger than the physiological size of the lacrimal duct, the fixation effect is poor, and the incidence of shedding is high

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