A kind of hydrogel and its application

A technology of hydrogel and cross-linking agent, which is applied in prosthesis, medical science, etc., can solve the problems of high hardness, difficulty in bending deformation, high lumen blockage rate, poor biocompatibility, etc. Into the cycle, the effect of convenient modification

Active Publication Date: 2020-09-11
广州锐澄医疗技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the common artificial nasolacrimal duct stents are mainly made of the following materials: (1) Metal materials: mostly made of alloys, with good supporting effect, but high hardness, not easy to bend and deform, high lumen blockage rate, and many complications , which is rarely used at present; (2) glass: good supporting effect, but obvious foreign body sensation; (3) medical silicone rubber: stable physical and chemical properties, non-toxic, no rejection; The small nasolacrimal duct is squeezed and narrowed, which affects the curative effect; (4) Polyurethane: moderate hardness, better supporting effect, but poor biocompatibility, long-term insertion is easy to induce body rejection and chronic inflammation

Method used

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  • A kind of hydrogel and its application
  • A kind of hydrogel and its application

Examples

Experimental program
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Effect test

Embodiment 1

[0023] One embodiment of the hydrogel of the present invention comprises the following preparation raw materials in parts by weight: 40 parts of hydroxyethyl methacrylate, 20 parts of crosslinking agent, 40 parts of water, 5 parts of thermal initiator and 10 parts of catalyst;

[0024] Wherein, the crosslinking agent is polyethylene glycol diacrylate, the thermal initiator is azobisisobutyronitrile, and the catalyst is N,N,N',N'-tetramethylethylenediamine.

[0025] An artificial nasolacrimal duct comprising the hydrogel described in this embodiment.

Embodiment 2

[0027] An embodiment of the hydrogel of the present invention, the difference between the hydrogel of this embodiment and Example 1 is that the ratio of the thermal initiator and the catalyst is different, and the hydrogel of the present embodiment contains the following weight Parts of raw materials for preparation: 40 parts of hydroxyethyl methacrylate, 20 parts of crosslinking agent, 40 parts of water, 5 parts of thermal initiator and 5 parts of catalyst;

[0028] Wherein, the crosslinking agent is polyethylene glycol diacrylate, the thermal initiator is azobisisobutyronitrile, and the catalyst is N,N,N',N'-tetramethylethylenediamine.

[0029] An artificial nasolacrimal duct comprising the hydrogel described in this embodiment.

Embodiment 3

[0031] An embodiment of the hydrogel of the present invention, the difference between the hydrogel of this embodiment and Example 1 is that the ratio of the thermal initiator and the catalyst is different, and the hydrogel of the present embodiment contains the following weight Parts of raw materials for preparation: 40 parts of hydroxyethyl methacrylate, 20 parts of crosslinking agent, 40 parts of water, 5 parts of thermal initiator and 15 parts of catalyst;

[0032] Wherein, the crosslinking agent is polyethylene glycol diacrylate, the thermal initiator is azobisisobutyronitrile, and the catalyst is N,N,N',N'-tetramethylethylenediamine.

[0033] An artificial nasolacrimal duct comprising the hydrogel described in this embodiment.

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Abstract

Provided is a hydrogel, comprising the following raw materials in parts by weight: 10-80 parts of hydroxyethyl methacrylate, 1-20 parts of a crosslinking agent, 10-80 parts of water, and 0.042-36 parts of a reaction initiator. The crosslinking agent is at least one of poly(ethylene glycol) diacrylate, ethylene glycol dimethacrylate, and triallyl isocyanurate. The reaction initiator is a mixture of a thermal initiator and a catalyst or a photoinitiator. The hydrogel has good hydrophilic properties, strong mechanical properties, and good biocompatibility and stability in the human body. Also provided is an artificial nasolacrimal duct containing the hydrogel. The artificial nasolacrimal duct has high tear guiding efficiency and good biocompatibility and stability, can achieve a longer implantation period, and does not easily cause rejection and inflammatory reactions in long-term implantation, is capable of expanding after water absorption and achieving a self-fixation effect, and involves a simple implantation process and easy operation.

Description

technical field [0001] The invention relates to a polymer material, in particular to a hydrogel and its application. Background technique [0002] The nasolacrimal ducts are two ducts that discharge tears from the eyes into the nasal cavity. The one located in the bony official cavity is called the inner bone, which is about 12.4mm, and the one located in the mucosa of the outer wall of the nasal cavity is called the inner nasal cavity, which is about 5.32mm long. Epiphora is a common and relatively common eye disease. It is a frequently-occurring disease caused by tear fluid stagnation in the lacrimal sac due to stenosis or blockage of the nasolacrimal duct. Patients with this disease will cry for a long time, which seriously affects the quality of life of the patient. At present, the traditional treatment methods for such diseases are mainly lacrimal duct probing and dacryocystorhinostomy, but this type of operation is not only complicated to operate, seriously damaged, bu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/18C08J3/075C08F220/20C08F220/28A61L27/52A61L27/50A61L27/16A61L27/18
CPCA61L27/16A61L27/18A61L27/50A61L27/52C08F220/20C08J3/075C08J2333/14C08L33/066C08L71/02C08F220/286
Inventor 李锐聪杨习锋曾晨光
Owner 广州锐澄医疗技术有限公司
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