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A pediatric calcium carbonate d 3 particles

A calcium carbonate, granule technology, applied in the direction of aluminum/calcium/magnesium active ingredients, metabolic diseases, drug combinations, etc. less effect

Active Publication Date: 2019-12-27
浙江寰领医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to solve existing calcium carbonate D 3 The defects of poor dissolution rate of granules and short use period after opening provide a high dissolution rate and extended shelf life of children's calcium carbonate D 3 particles

Method used

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  • A pediatric calcium carbonate d <sub>3</sub> particles
  • A pediatric calcium carbonate d <sub>3</sub> particles
  • A pediatric calcium carbonate d <sub>3</sub> particles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A Pediatric Calcium Carbonate D 3 Granules, the Pediatric Calcium Carbonate D 3 Particles include the following components in parts by weight: 760 parts of calcium carbonate particles, vitamin D 3 1.2 parts of inclusion powder granules, 250 parts of auxiliary materials and 0.8 parts of tocopherol.

[0039] The vitamin D 3 The preparation method of inclusion powder particles is as follows: polydextrose is dissolved in pure water to obtain a polydextrose solution; the vitamin D 3 Dissolve in absolute ethanol, slowly drop into the polydextrose solution at 65°C, oscillate at 120w for 30min, cool and filter, crystallize, wash, dry and pulverize through a 120-mesh sieve.

[0040] The polydextrose and vitamin D 3 The molar ratio is 10:1.

[0041] Particle size distribution of calcium carbonate particles and vitamin D 3 The particle size distribution of inclusion powder particles is consistent.

[0042] The auxiliary materials include glucose, maltodextrin, sodium carbox...

Embodiment 2

[0051] A Pediatric Calcium Carbonate D 3 Granules, the Pediatric Calcium Carbonate D 3 The particles include the following components in parts by weight: 750 parts of calcium carbonate particles, vitamin D 3 1 part of inclusion powder granules, 248 parts of auxiliary materials and 0.58 parts of tocopherol.

[0052] The vitamin D 3 The preparation method of inclusion powder particles is as follows: polydextrose is dissolved in pure water to obtain a polydextrose solution; the vitamin D 3 Dissolve in absolute ethanol, slowly drop into the polydextrose solution at 65°C, oscillate at 120w for 30min, cool and filter, crystallize, wash, dry and pulverize through a 120-mesh sieve.

[0053] The polydextrose and vitamin D 3 The molar ratio is 10:1.

[0054] Particle size distribution of calcium carbonate particles and vitamin D 3 The particle size distribution of inclusion powder particles is consistent.

[0055] The auxiliary materials include glucose, maltodextrin, sodium carb...

Embodiment 3

[0064] A Pediatric Calcium Carbonate D 3 Granules, the Pediatric Calcium Carbonate D 3 Particles include the following components in parts by weight: 740 parts of calcium carbonate particles, vitamin D 3 0.8 parts of inclusion powder granules, 245 parts of excipients and 0.5 parts of tocopherol.

[0065] The vitamin D 3 The preparation method of inclusion powder particles is as follows: polydextrose is dissolved in pure water to obtain a polydextrose solution; the vitamin D 3 Dissolve in absolute ethanol, slowly drop into the polydextrose solution at 65°C, oscillate at 120w for 30min, cool and filter, crystallize, wash, dry and pulverize through a 120-mesh sieve.

[0066] The polydextrose and vitamin D 3 The molar ratio is 10:1.

[0067] Particle size distribution of calcium carbonate particles and vitamin D 3 The particle size distribution of inclusion powder particles is consistent.

[0068] The auxiliary materials include glucose, maltodextrin, sodium carboxymethyl c...

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Abstract

The invention belongs to the field of pharmaceutical preparations and relates to calcium carbonate D3 granules for children, which have high dissolvability and prolonged shelf life. The calcium carbonate D3 granules for the children are prepared from the following components in parts by weight: 740 to 760 parts of calcium carbonate granules, 0.8 to 1.2 parts of calcium carbonate D3 inclusion powder granules, 245 to 250 parts of an auxiliary material and 0.5 to 0.8 part of tocopherol. The calcium carbonate D3 granules, provided by the invention, has the advantage of few prescription componentsand simple and easy-to-obtain auxiliary materials; the granularity of raw and auxiliary material powder, the dosage of raw and auxiliary materials and a preparation technology are effectively controlled so that the uniformity of the granules is improved and the calcium carbonate D3 granules have higher dissolubility and vitamin D3 content; and the obedience of oral administration is enhanced and the absorption on calcium of human bodies is facilitated. The preparation and the preparation technology are feasible and are suitable for large-scale production.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations and relates to a calcium carbonate granule, in particular to a calcium carbonate D for children with high dissolution rate and extended shelf life 3 particles. Background technique [0002] Calcium carbonate has high calcium content, low price, and high safety. It is currently recognized as the calcium source with the highest performance-price ratio at home and abroad. It has been widely used as the first choice raw material for calcium supplement preparations by domestic and foreign pharmaceutical companies. Calcium carbonate is insoluble in water, and its ordinary solid preparation products need to react with gastric acid to produce ionized calcium that can be absorbed by the human body after taking it, resulting in a large consumption of gastric acid, which is not up to expectations for those with achlorhydria, children and the elderly For the purpose of calcium supplementation, it w...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K33/10A61K31/593A61K31/355A61K47/36A61K47/38A61K47/26A61K47/12A61K47/24A61P3/02
CPCA61K9/1617A61K9/1623A61K9/1652A61K31/355A61K31/593A61K33/10A61K2300/00
Inventor 胡林水张帅许青聊李辉
Owner 浙江寰领医药科技有限公司
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