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Pharmaceutical composition containing narcissoside as well as preparation method and application thereof

A composition and the technology of narciscoside, which are applied in the pharmaceutical composition containing narciscoside and its preparation field, can solve the problems such as lowering blood fat of narciscoside which has not been disclosed, and achieve the effect of low price, wide application prospect and guaranteed curative effect

Inactive Publication Date: 2018-03-06
朗致集团万荣药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Narciscoside is derived from Fructus japonica. At present, there is no report about Narciscoside in reducing blood lipids. In addition, there is no disclosure of the application of compositions including Narciscoside for reducing blood lipids. The form of the composition is a drug substance used for lowering blood lipids

Method used

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  • Pharmaceutical composition containing narcissoside as well as preparation method and application thereof
  • Pharmaceutical composition containing narcissoside as well as preparation method and application thereof
  • Pharmaceutical composition containing narcissoside as well as preparation method and application thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0042] The pharmaceutical composition containing narcissin in this embodiment includes 0.7 mg of narcisin, 6.5 mg of pinitol, 2 mg of paclitaxel, mixed with water and auxiliary materials to prepare a sterile solution with a pH value of 7.0, wherein the narcisin is in the aseptic The content in the bacterial solution is 0.14 mg / mL, the content of pinitol is 1.3 mg / mL, and the content of paclitaxel is 0.4 mg / mL.

Embodiment 2

[0044] The pharmaceutical composition containing daffodil in this embodiment includes the following components: 0.5 mg daffodil, 15 mg pinitol, 3 mg paclitaxel, 1.0 mg ginkgolide A, 0.7 mg ginkgolide B, and 0.8 mg ginkgolide C;

[0045] The pinitol, paclitaxel, ginkgolide A, ginkgolide B, ginkgolide C and daffodil of the above-mentioned selected parts by weight are mixed with water and auxiliary materials to make a sterile solution with a pH value of 5.0, wherein the The content of narciscin in the sterile solution is 0.10mg / mL, the content of pinitol is 3mg / mL, the content of paclitaxel is 0.6mg / mL, ginkgolide A 0.2mg / mL, ginkgolide B 0.14mg / mL, ginkgolide C 0.16mg / mL.

Embodiment 3

[0047] The pharmaceutical composition containing narciscine in this example includes the following components: 1 mg narciscine, 6 mg pinitol, 3 mg paclitaxel, 2 mg ginkgolide A, 1 mg ginkgolide B, 1 mg ginkgolide C;

[0048] The pinitol, paclitaxel, ginkgolide A, ginkgolide B, ginkgolide C and narcissin of above-mentioned selected parts by weight are mixed with water and auxiliary materials to make a sterile solution with a pH value of 6.0, wherein the The content of narciscin in the sterile solution is 0.06mg / mL, the content of pinitol is 1.2mg / mL, the content of paclitaxel is 0.2mg / mL, ginkgolide A 0.1mg / mL, ginkgolide B 0.05mg / mL, ginkgolide C 0.07mg / mL.

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PUM

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Abstract

The invention provides a pharmaceutical composition containing narcissoside as well as a preparation method and application thereof. The pharmaceutical composition is prepared from the following components according to the specific weight part: the narcissoside, pinitol and sequoyitol; all the components of the pharmaceutical composition have mutual matching and synergistic effects under the specific ratio, so that the pharmaceutical composition provided by the invention has a blood lipid lowering effect.

Description

technical field [0001] The invention relates to the field of pharmaceutical compositions, in particular to a pharmaceutical composition containing narcissin, a preparation method and application thereof. Background technique [0002] Hyperlipidemia is a systemic disease, which means that the concentration of blood lipid components such as plasma cholesterol, triglycerides, and total lipids exceeds the normal standard. Lipids are insoluble or slightly soluble in water, and must be combined with proteins to exist in the form of lipoproteins. Therefore, Hyperlipidemia is also commonly referred to as hyperlipoproteinemia. Hyperlipidemia can lead to atherosclerosis, which in turn leads to many related diseases such as hypertension, diabetes and coronary heart disease, which seriously endanger human health. Therefore, it is imperative to control hyperlipidemia. Narciscoside is derived from Trichosanthes fragrans. At present, there is no report about Narciscoside in lowering blood...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K31/075A61K31/365A61P3/06
CPCA61K31/7048A61K31/075A61K31/365A61K2300/00
Inventor 王锋杨满辉
Owner 朗致集团万荣药业有限公司
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