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Graphene-coated copper-based biomaterial and its preparation method and application

A graphene wrapping and graphene technology, applied in the field of materials, can solve the problems of tissue necrosis, copper-based materials not widely used in organisms, edema, etc., and achieve the effect of eliminating toxicity and good coating effect

Active Publication Date: 2020-07-24
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, studies have shown that copper will spontaneously corrode in biological tissues to produce copper ions, which will cause tissue necrosis and edema
Therefore, although copper has good conductivity and low price, copper-based materials have not been widely used in living organisms.

Method used

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  • Graphene-coated copper-based biomaterial and its preparation method and application
  • Graphene-coated copper-based biomaterial and its preparation method and application
  • Graphene-coated copper-based biomaterial and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Embodiment 1, prepare the composite material wrapped by graphene

[0051] A commercially available copper wire (alfa#10971) with a diameter of 100 microns is placed in a chemical vapor deposition device, and the copper wire is supported by a copper foil to ensure that one end of the copper wire has a length of 1 cm without physical contact with the copper foil (that is, a suspended end), carefully put it into the open quartz boat and then push it into the center of the 1-inch quartz tube together, evacuate to 0.7Pa with a mechanical pump, pass through the 200sccm Ar gas scrubbing path for 30min, then close the Ar, and pass in the hydrogen gas with a flow rate of 100sccm, from room temperature Raise the temperature to 1100°C with a heating rate of 26°C / min, keep at 1010°C and hydrogen atmosphere constant annealing for 1h, then feed 10sccm carbon source gas methane for 40min to make graphene chemical vapor deposition on the copper wire, then Cool down to room temperature ...

Embodiment 2

[0062] The performance of the composite material of embodiment 2, embodiment 1 gained graphene wrapping

[0063] 1.1 In vitro cell culture experiments

[0064] 1.1.1 Cellcountkit-8 kit detection

[0065] In order to detect the survival rate of cells after exposure to samples, the CCK-8 kit was used in this experiment. Cell Counting Kit-8 (CCK-8 for short) reagents can be used for simple and accurate analysis of cell proliferation and toxicity. The basic principle is: WST-8(2-(2-methoxy-4-nitrophenyl)-3-(4-nitrophenyl)-5-(2,4 -disulfonic acid phenyl)-2H-tetrazole monosodium salt) is dehydrogenated in cells under the action of electron carrier 1-methoxy-5-methylphenazinium dimethyl sulfate (1-Methoxy PMS) The enzyme reduces to formazan dye, which is highly water soluble. The amount of orange-yellow formazan product produced by the reaction is proportional to the number of living cells, so the absorbance of the solution is also proportional to the number of living cells.

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Abstract

The invention discloses a graphene cladded copper-base biological material as well as a preparation method and an application thereof. The graphene-packaged composite material contains copper and graphene, wherein the surface of copper is totally packaged with graphene. The material has a good cladding effect, the toxin introduced by copper can be eliminated, and the death of cells and the necrosis and edema of tissues are avoided. The material can be taken as an electrode, particularly a neural electrode and can be applied to an in vivo or in vitro signal recording such as the signal recording of neuronal discharging and / or local field potential change. The material and a commercial platinum-iridium alloy electrode do not generate an artifact in a nuclear magnetic resonance imaging technique, and the observation of the quality and an implementation position of a nuclear magnetic resonance is greatly assisted.

Description

technical field [0001] The invention belongs to the field of materials, and relates to a graphene-coated copper-based biological material and a preparation method and application thereof. Background technique [0002] Graphene is a two-dimensional film material composed of a single layer of carbon atoms arranged in a hexagonal symmetrical honeycomb structure. Graphene is a flat film with a hexagonal lattice structure composed of a single layer of carbon atoms tightly packed in sp2 hybrid orbitals. It is a two-dimensional carbon material with a thickness of only one carbon atom. Graphene has excellent electrical conductivity, high room temperature charge mobility, and high mechanical strength, as well as a large specific surface area. More importantly, graphene also has excellent electrochemical properties. The Manchester group that first isolated graphene measured the single-layer graphene they separated and found that the charge transfer rate exceeded 15,000 cm 2 ·V -1 ·...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/08A61L31/02A61L31/14C23C16/26
CPCA61L31/024A61L31/088A61L31/14A61L2420/02C23C16/26
Inventor 段小洁赵思源刘小军徐政
Owner PEKING UNIV
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