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Method for coating sevelamer carbonate tablets

A sevelamer carbonate and coating technology, which is applied in the coating field of sevelamer carbonate tablets, can solve the problem of tablet core powder dropping, achieve the effects of preventing moisture absorption, suppressing powder dropping, and improving product quality

Inactive Publication Date: 2018-04-20
南京恒生制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The purpose of the present invention is to overcome the problem that tablet core drops powder in the coating process of carbonic acid sevelamer tablet, a kind of feasible film coating process is provided

Method used

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  • Method for coating sevelamer carbonate tablets
  • Method for coating sevelamer carbonate tablets
  • Method for coating sevelamer carbonate tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Put 800g of sevelamer carbonate (calculated as the dry product) and 100g of microcrystalline cellulose in a wet mixing granulator and mix well, add about 50g of purified water (to make the total water content of the material 11%), and granulate , Add 5 g of magnesium stearate and mix until uniform, and prepare sevelamer carbonate tablet cores with a tablet press. Dissolve or suspend 50 g of Opadry Clear, a coating material, with 450 g of purified water, and set aside. Place the sevelamer carbonate tablet cores in the high-efficiency coating machine, start the main machine of the coating machine, make the cores turn continuously in the pan, control the core temperature, turn on the spray gun, and spray the prepared coating liquid on On the surface of the tablet core, after the tablet core has a layer of coating material, heat the tablet core and control the temperature, and continue to spray the coating liquid until the surface of the sevelamer carbonate tablet is smooth,...

Embodiment 2

[0034] Put 800g of sevelamer carbonate (calculated as the dry product) and 100g of microcrystalline cellulose in a wet mixing granulator and mix well, add about 50g of purified water (to make the total water content of the material 11%), and granulate , Add 5 g of magnesium stearate and mix until uniform, and prepare sevelamer carbonate tablet cores with a tablet press. Dissolve or suspend 50 g of Opadry Clear, a coating material, with 450 g of purified water, and set aside. Place the sevelamer carbonate tablet cores in the high-efficiency coating machine, start the main machine of the coating machine, make the cores turn continuously in the pan, control the core temperature, turn on the spray gun, and spray the prepared coating liquid on On the surface of the tablet core, after the tablet core has a layer of coating material, heat the tablet core and control the temperature, and continue to spray the coating liquid until the surface of the sevelamer carbonate tablet is smooth,...

Embodiment 3

[0040] Put 800g of sevelamer carbonate (calculated as the dry product) and 100g of microcrystalline cellulose in a wet mixing granulator and mix well, add about 50g of purified water (to make the total water content of the material 11%), and granulate , Add 5 g of magnesium stearate and mix until uniform, and prepare sevelamer carbonate tablet cores with a tablet press. Dissolve or suspend 50 g of Opadry Clear, a coating material, with 450 g of purified water, and set aside. Place the sevelamer carbonate tablet cores in the high-efficiency coating machine, start the main machine of the coating machine, make the cores turn continuously in the pan, control the core temperature, turn on the spray gun, and spray the prepared coating liquid on On the surface of the tablet core, after the tablet core has a layer of coating material, heat the tablet core and control the temperature, and continue to spray the coating liquid until the surface of the sevelamer carbonate tablet is smooth,...

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Abstract

The invention discloses a method for coating sevelamer carbonate tablets. The method comprises the following steps: under the condition that the temperature of a tablet core is controlled to 20-40 DEGC at an initial coating stage, directly spraying a coating liquid to a sevelamer carbonate tablet core, at the same time controlling the water content of the tablet core to 7-15%, after the tablet core is coated by a layer of a coating material, heating the tablet core to 30-50 DEG C, and continuously coating the tablet core till the surface of a sevelamer carbonate tablet is smooth. By adoptingthe method, the problems that powder drops from the sevelamer carbonate tablet at the coating stage, and the surface of the sevelamer carbonate tablet is rough and has hidden spots, are very well solved.

Description

Technical field [0001] The invention relates to the field of drug coating, and relates to a coating method of sevelamer carbonate tablets, in particular to a coating method of sevelamer carbonate tablets. Background technique [0002] At present, coating methods mainly include sugar coating, film coating, etc. Among them, film coating technology has been used in the pharmaceutical field for many years and is mainly used in tablets for moisture-proof, light-proof, taste-masking, sustained and controlled release, and selective release. The coating effect is mainly affected by factors such as the properties of the plain tablets, the composition of the coating liquid and the coating process. [0003] Sevelamer carbonate, also known as cross-linked polyallylamine carbonate, is a cationic polymer. It carries multiple amine groups that can be protonated in the small intestine and become positively charged through ion exchange and hydrogen bonding. Binds to phosphate in the small intestin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/28A61K31/785
CPCA61K9/2893A61K31/785
Inventor 韦超王芳方文刘勇
Owner 南京恒生制药有限公司
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