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Application of tetrastigma hemsleyanum comprehensive extract in preparation of drugs controlling rheumatoid arthritis

A comprehensive extraction and rheumatoid technology, applied in the field of medicine, can solve problems such as limited application, difficulty in controlling curative effect, and difficulty in clarifying the mechanism of action, and achieve the effect of simple preparation method, wide source of raw materials, and good development prospects

Inactive Publication Date: 2018-04-20
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the complexity of traditional Chinese medicine ingredients, it is difficult to clarify the mechanism of action and control the curative effect, which limits its clinical application

Method used

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  • Application of tetrastigma hemsleyanum comprehensive extract in preparation of drugs controlling rheumatoid arthritis
  • Application of tetrastigma hemsleyanum comprehensive extract in preparation of drugs controlling rheumatoid arthritis
  • Application of tetrastigma hemsleyanum comprehensive extract in preparation of drugs controlling rheumatoid arthritis

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Experimental program
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Effect test

Embodiment

[0023] 1. Preparation of Clover comprehensive extract

[0024] Take the dry tubers of Clover and break them into pieces. Take 5000g Clover, add 6 times the weight and mass concentration of 70% ethanol solution, soak for 1h, then heat and reflux for extraction 3 times, each time for 2h, combine the extracts, vacuum at low temperature (vacuum degree-0.085MPa, temperature 40°C) The alcohol is recovered to obtain a concentrated solution.

[0025] The concentrated solution was extracted three times with 5L of petroleum ether, the obtained petroleum ether layer was separated from the water layer, and the petroleum ether extract was recovered to obtain the petroleum ether extract. The separated water layer was extracted three times with 5 liters of ethyl acetate, the ethyl acetate layer was separated from the obtained water layer, and ethyl acetate was recovered from the ethyl acetate extract to obtain the ethyl acetate extract. The water layer is extracted 3 times with 4L n-butano...

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Abstract

Belonging to the technical field of medicine, the invention in particular relates to application of a tetrastigma hemsleyanum comprehensive extract in preparation of drugs controlling rheumatoid arthritis. Animal experiments verify that the tetrastigma hemsleyanum comprehensive extract extracted from tetrastigma hemsleyanum can effectively alleviate the foot swelling degree of CIA mice, significantly inhibit the joint lesions of CIA mice and show good therapeutic effect, from the aspect of genetic expression, the tetrastigma hemsleyanum comprehensive extract can inhibit the expression of RORgammat and RANKLmRNA genes, thus controlling rheumatoid arthritis.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to the application of a trefoil extract in the preparation of medicines for preventing and treating rheumatoid arthritis. Background technique [0002] Clover clover, also known as clover vine, snake monkshood, stone mouse, etc., is a herbaceous vine of the family Vitis genus, and the whole plant can be used as medicine. The medicinal effect of underground tubers and fruits is the best. Clover has the effects of "clearing heat and detoxifying, anti-inflammatory and analgesic, promoting blood circulation and removing blood stasis". [0003] Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic, progressive, and aggressive arthritis. The prevalence of RA in my country is 0.3% to 0.5%. It is one of the main diseases that cause the loss of labor force and disability of the Chinese population, and it causes huge economic losses to individuals ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/87A61P19/02A61K125/00
CPCA61K36/87A61K2236/333A61K2236/39A61K2236/51A61K2236/53
Inventor 曹岗吴鑫寿旗扬
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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