Biomedical detection system based on nanoimprinted microfluidic chip and manufacturing method thereof

A microfluidic chip and nano-imprint technology, which is applied in the field of biomedical detection, can solve the problems of insufficient miniaturization of sensor chips, and achieve the effects of easy production and promotion, good light transmission, and convenient detection.

Pending Publication Date: 2018-04-20
厦门百恩芯科技有限公司
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  • Application Information

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Problems solved by technology

[0003] However, it is not enough to only miniaturize the sensor chip. How to complete large

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  • Biomedical detection system based on nanoimprinted microfluidic chip and manufacturing method thereof
  • Biomedical detection system based on nanoimprinted microfluidic chip and manufacturing method thereof
  • Biomedical detection system based on nanoimprinted microfluidic chip and manufacturing method thereof

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Embodiment Construction

[0049] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0050] In the embodiment of the present invention, the microfluidic chip 5 and the SPR detection chip 10 are bonded, and then the detection chip 13, which is bonded to the SPR sensor chip carrying the sample to be detected and the microfluidic chip, is loaded into the fixture, and illuminated by an LED lamp. The detection chip 13 combined with the SPR sensor chip and the microfluidic chip makes it produce the SPR effect, and transmits the emitted light to the c...

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Abstract

The invention discloses a biomedical detection system based on a nanoimprinted microfluidic chip and a manufacturing method thereof, including a microfluidic chip, an SPR detection chip, a mechanical fixture and an annular LED light-emitting array. , nano-imprint glue, chromium film and gold film are compounded from bottom to top; the microfluidic chip is equipped with multiple sets of microfluidic channels made of SU‑8 glue photolithography and PDMS film formation, and the microfluidic channels It is mainly composed of an S-shaped microfluidic channel and a sample feeding channel and an outflow channel connected at both ends. The invention adopts the microfluidic technology, and can realize multi-channel parallel rapid detection on a small chip with very few reagents by arranging micropipes on the nanoimprinted sensor chip to process or manipulate tiny fluids. At the same time, a mechanical fixture is used to connect the detection chip with the embedded device to form a detection system, which can conveniently use the information processing function of the embedded device to complete the automatic detection process.

Description

technical field [0001] The invention relates to the field of biomedical detection, in particular to a biomedical detection system based on nano-imprinted microfluidic chips and a manufacturing method thereof. Background technique [0002] With the development of contemporary science and technology, people have higher and higher requirements for small, fast and parallel detection technology of multiple substances, especially in the field of biomedicine. Smaller and faster detection methods can help people better detect themselves The physical condition can even be tested without leaving home. The sensor based on surface plasmon resonance (Surface Plasmon Resonance, SPR) technology provides a new idea for the miniaturization of the detection chip. SPR is a physical optical phenomenon caused by the interaction between light waves and metal electrons. When the vector component of the light wave propagating along the metal interface is equal to the vector component of the surfac...

Claims

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Application Information

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IPC IPC(8): B01L3/00G01N21/55H01L21/18
CPCG01N21/55B01L3/5027B01L2200/10B01L2300/0861B01L2300/12H01L21/187
Inventor 朱锦锋吴秋斌高云之
Owner 厦门百恩芯科技有限公司
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