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Application of tea peptides to relieving diabetic nephropathy

A technology for diabetic nephropathy and diabetes, which is applied in the field of biopharmaceuticals, can solve the problems of research and reporting of tea polypeptide treatment and relief effects, and achieve the effects of improving insulin resistance, increasing sensitivity, and lowering blood sugar levels

Inactive Publication Date: 2018-04-24
TEA RES INST GUANGDONG ACAD OF AGRI SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, in the research on the treatment and alleviation of diabetic nephropathy, there is no research and report on the treatment and alleviation effect of tea peptides

Method used

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  • Application of tea peptides to relieving diabetic nephropathy
  • Application of tea peptides to relieving diabetic nephropathy
  • Application of tea peptides to relieving diabetic nephropathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0018] The following examples are some examples of the present invention, and should not be regarded as limiting the present invention.

[0019] 1. Extraction of tea polypeptide

[0020] Tea polypeptides were extracted from tea dregs, and then the amino acids in tea polypeptides were detected. Among them, the hydrated amino acids (Content of hydrolyzed amino acid) and free amino acids (Content of free amino acids) of acidic tea polypeptides (AcTP) and alkaline tea polypeptides (AlTP) acid) content and composition are shown in Table 1.

[0021] Table 1 Amino acid composition of tea polypeptides (mean±SD)

[0022]

[0023]

[0024] 2. Study on the data and mitigation effect of tea polypeptide on diabetic nephropathy

[0025] 1. Build the model

[0026] A diabetic nephropathy model was prepared by intraperitoneal injection of high-sugar and high-fat diet plus streptozotocin (STZ, 60mg / kg), wherein the high-sugar and high-fat diet contained 16.46% protein, 45.65% fat and ...

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Abstract

The invention belongs to the field of biomedicine and particularly relates to application of tea peptides to relieving diabetic nephropathy. Compared with the prior art, the application of the tea peptides to relieving diabetic nephropathy provides a new method and research theory for treating and relieving diabetic nephropathy; study and experiment shows that the tea peptides extracted from tea residues achieve good relieving effects on diabetic nephropathy to effectively reduce sugar content of blood, increase sensitivity of serum insulin and improve insulin resistance; besides, research anddevelopment of the tea peptides extracted from the tea residues is of significance and value to further deep study on tea functions, thereby having a broad potential marketing and application prospect.

Description

technical field [0001] The invention belongs to the field of biopharmaceuticals, and specifically relates to the application of tea polypeptide in alleviating diabetic nephropathy. Background technique [0002] In recent years, China has become one of the regions with the highest incidence of diabetes in the world. With the rapid increase in the number of diabetic patients, diabetic nephropathy has become the main cause of advanced kidney disease, and is the main cause of morbidity and death in diabetic patients. [0003] Diabetic nephropathy is manifested as kidney enlargement at the earliest stage. As the disease progresses, glomerular capillaries gradually show thickening of basement membrane, proliferation of mesangial cells, and increase of mesangial matrix; further development may lead to proteinuria, glomerulosclerotic lesions and Tubulointerstitial fibrosis eventually leads to renal failure. Exploring effective treatment methods and drugs for diabetic nephropathy ha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/02A61P3/10A61P13/12
CPCA61K38/02
Inventor 孙伶俐张灵枝邓旭铭赖幸菲孙世利黎秋华向丽敏
Owner TEA RES INST GUANGDONG ACAD OF AGRI SCI
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