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Medical film having antibacterial function and preparation method thereof

A functional, carboxymethyl chitosan technology, applied in the field of medical supplies, can solve the problems of poor biocompatibility, unsatisfactory effect, poor antibacterial performance, etc., and achieve the effect of promoting healing, preventing wound infection, and excellent liquid absorption performance

Inactive Publication Date: 2018-04-27
张立栋
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the existing medical membranes are highly irritating to the skin, have disadvantages such as poor antibacterial performance, poor biocompatibility, and slow wound healing. When dealing with chronic wounds, the effect is often not ideal.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A medical film with antibacterial function, its composition by weight: 30 parts of carboxymethyl chitosan, 6 parts of polylactic acid, 20 parts of stearic acid, 20 parts of sodium alginate, 5 parts of glycerin, 12 parts of gelatin, 3.5 parts of honeysuckle, 1.8 parts of Sanhuang powder, 4.2 parts of licorice, and 3 parts of polyvinyl alcohol.

[0025] A kind of medical film with antibacterial function, its preparation method comprises the following steps:

[0026] a. Put honeysuckle, Sanhuang powder and licorice into a pulverizer for pulverization, then sieve and set aside;

[0027] b. Add carboxymethyl chitosan, polylactic acid, stearic acid, sodium alginate, glycerin, gelatin and polyvinyl alcohol into a blender, mix and stir evenly, and set aside;

[0028] c. Put the honeysuckle, sanhuang powder and licorice crushed in step a into the ethanol solution, pressurize to 0.3MPa, and continuously reflux and extract for 4 hours at 70°C, take out the extract to obtain mixed...

Embodiment 2

[0038] A medical film with antibacterial function, its composition by weight: 35 parts of carboxymethyl chitosan, 5 parts of polylactic acid, 25 parts of stearic acid, 10 parts of sodium alginate, 10 parts of glycerin, 10 parts of gelatin, 4.5 parts of honeysuckle, 1.1 parts of Sanhuang powder, 5.4 parts of licorice, and 1 part of polyvinyl alcohol.

[0039] A kind of medical film with antibacterial function, its preparation method comprises the following steps:

[0040] a. Put honeysuckle, Sanhuang powder and licorice into a pulverizer for pulverization, then sieve and set aside;

[0041] b. Add carboxymethyl chitosan, polylactic acid, stearic acid, sodium alginate, glycerin, gelatin and polyvinyl alcohol into a blender, mix and stir evenly, and set aside;

[0042] c. Put the honeysuckle, sanhuang powder and licorice crushed in step a into the ethanol solution, pressurize to 0.4MPa, and continuously reflux and extract for 5 hours at 73°C, take out the extract to obtain mixed...

Embodiment 3

[0052] A medical film with antibacterial function, its composition by weight: 40 parts of carboxymethyl chitosan, 8 parts of polylactic acid, 30 parts of stearic acid, 35 parts of sodium alginate, 15 parts of glycerin, 15 parts of gelatin, 5.5 parts of honeysuckle, 3.2 parts of Sanhuang powder, 6.6 parts of licorice, and 7 parts of polyvinyl alcohol.

[0053]A kind of medical film with antibacterial function, its preparation method comprises the following steps:

[0054] a. Put honeysuckle, Sanhuang powder and licorice into a pulverizer for pulverization, then sieve and set aside;

[0055] b. Add carboxymethyl chitosan, polylactic acid, stearic acid, sodium alginate, glycerin, gelatin and polyvinyl alcohol into a blender, mix and stir evenly, and set aside;

[0056] c. Put the crushed honeysuckle, sanhuang powder and licorice in the ethanol solution, pressurize to 0.5MPa, and continuously reflux and extract for 6 hours at 76°C, take out the extract to obtain mixed component A...

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PUM

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Abstract

The invention relates to the technical field of medical supplies, in particular to a medical film having an antibacterial function and a preparation method thereof. The medical film is composed of, byweight, 30-50 parts of carboxymethyl chitosan, 5-8 parts of polylactic acid, 20-40 parts of stearic acid, 10-35 parts of sodium alginate, 5-20 parts of glycerin, 10-15 parts of gelatin, 3.5-6.5 partsof honeysuckle, 1.1-3.2 parts of Sanhuangfen, 4.2-8.4 parts of radix glycyrrhizae and 1-7 parts of polyvinyl alcohol. Pathogenic bacteria killing effect of the medical film prepared by the method iseffectively improved, the medical film has good antibacterial effect and can effectively prevent wound infection, potential biosafety risk of the medical film is lowered, bacteriostatic rate of the medical film is increased, a moist healing environment is provided for a wound, and healing of the surface of the wound is promoted; the medical film has high biocompatibility, is nonirritant to skin and tissue, can be softly pasted on the surface of the skin and makes a user more comfortable.

Description

technical field [0001] The invention relates to the technical field of medical supplies, in particular to a medical film with antibacterial function and a preparation method thereof. Background technique [0002] The skin is the largest organ of the human body, and it has important functions such as resisting the invasion of external microorganisms, excreting and preventing water evaporation, regulating body temperature, and maintaining the stability of the internal environment of the body. After the skin is damaged, it is urgent to repair the wound, and cover the wound with a layer of dressing to promote wound healing. With the continuous progress of society and the rapid development of medicine, many diseases have been effectively controlled, but the trauma continues unabated. For decades, scholars from all over the world have been committed to actively promoting wound repair through various therapies. With the deepening of research on wound healing, people realized that ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/46A61L15/40A61L15/42A61L15/28
CPCA61L15/46A61L15/28A61L15/40A61L15/42A61L2300/30A61L2300/404C08L5/08C08L5/04
Inventor 张立栋
Owner 张立栋