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Small molecular polypeptide promoting skin damage repair and application thereof

A technology for small molecular peptides and skin damage, applied in the field of biomedicine, can solve problems such as abnormal skin healing results and incomplete skin healing mechanisms, and achieve the effects of high affinity, reduced degradation and low production costs.

Active Publication Date: 2018-05-01
广州恒宁生物科技有限公司
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

Cells secrete cytokines to regulate wound healing, and cytokines in turn affect the function of cells. Any abnormality in any link may cause abnormal skin healing results, and the skin healing process is affected by many factors (age, nutritional status, endocrine changes, etc.) , drugs, local blood circulation, infection, ionizing radiation and systemic diseases, etc.), therefore, the mechanism of skin healing is still not fully understood

Method used

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  • Small molecular polypeptide promoting skin damage repair and application thereof
  • Small molecular polypeptide promoting skin damage repair and application thereof
  • Small molecular polypeptide promoting skin damage repair and application thereof

Examples

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Embodiment 1

[0031] 1. Detection of affinity between remodeling peptide SNFLHLG and FGFR2 by ITC method

[0032] The affinity detected by isothermal microcalorimeter (ITC) is as follows: figure 1 As shown, Figure A is the detection result of the binding force between the remodeling peptide T1 peptide and FGFR2, and their affinity constant K=3.11E7±1.63E6M -1 , the dissociation constant Kd≈32.1nM, Figure B shows the detection results of the binding force between bFGF and FGFR2, and their affinity constant is K=1.62E5±2.50E4M -1 , the dissociation constant Kd≈6.17 μM. The results showed that the affinity of the remodeling peptide T1 peptide to FGFR2 was much higher than that of bFGF to FGFR2, the former being about 200 times that of the latter. (K represents the affinity constant, Kd represents the dissociation constant, the larger the K, the smaller the Kd, the stronger the affinity).

[0033] 2. CCK-8 method was used to detect the pro-proliferative effects of remodeling peptides T1, T2,...

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Abstract

The invention discloses a small molecular polypeptide promoting skin damage repair and application thereof, belonging to the field of biological medicines. The small molecular polypeptide is consecutive four or more linear peptides or cyclic peptides of the length of 4-12 consecutive amino acid containing a core sequence of SNFLHLG. Compared with the existing similar product-a recombined bFGF forexternal use, the small molecular polypeptide has equivalent proliferation effect but higher affinity and smaller molecule weight; the small molecular polypeptide adopts a chemical synthesis method rather than a genetic engineering method, so that under the use condition of equal molar concentration, the production cost and use cost are lower, therefore, the small molecular polypeptide promoting skin wound repair and cell proliferation is an ideal product replacing the recombined bFGF. Compared with the bFGF, the polypeptide provided in the invention has several or a dozen of amino acid, thereby being decomposed much more easily; further, experimental results disclosed in the invention show that the polypeptide can keep acting on a to-be-treated position, thereby having technological advancement.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a small molecular polypeptide for promoting skin damage repair and its application. Background technique [0002] The skin is the largest tissue in the human body and the most direct contact with the outside world, and it is also the most vulnerable organ to be damaged by external stimuli. Normal wound healing is crucial to maintaining body homeostasis, while abnormal healing such as non-healing or delayed healing caused by extensive burns, chronic wound healing caused by other diseases, and abnormal healing such as the formation of pathological scars, etc. It not only affects the appearance, but also causes structural and functional obstacles, which often causes heavy psychological pressure on patients and seriously affects their physical and mental health. Therefore, how to quickly achieve the best healing effect in the treatment of skin wounds has always been a research...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K7/06C07K7/08C07K7/64A61K38/10A61K38/08A61K8/64A61Q19/00A61P17/02
CPCA61K8/64A61K38/00A61Q19/00C07K7/06C07K7/08C07K7/64
Inventor 陈小佳洪岸赵影
Owner 广州恒宁生物科技有限公司
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