Preparation method of zinc-doped hydroxyapatite coating used for magnesium alloy material

A technology of hydroxyapatite and magnesium alloy, which is applied in metal material coating technology, coating, pharmaceutical formulations, etc. It can solve the problems of difficult combination of strength and formability, many coating holes, and limited biocompatibility improvement effect, etc. problem, achieve the effects of reducing stress-induced defects, good product crystallization, and easy commercialization

Inactive Publication Date: 2018-05-08
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the large number of pores in the coating prepared by electrodeposition, the improvement of its biocompatibility is limited.
[0006] In addition, the existing techniques for preparing coatings on the surface of magnesium alloys, such as

Method used

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  • Preparation method of zinc-doped hydroxyapatite coating used for magnesium alloy material
  • Preparation method of zinc-doped hydroxyapatite coating used for magnesium alloy material

Examples

Experimental program
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Effect test

Embodiment 1

[0031] 1) Wire-cut the magnesium alloy substrate into a suitable size, and then polish it with 600#, 1500#, 2000# silicon carbide water-resistant sandpaper to remove the oxide layer on the surface of the magnesium alloy, then rinse it with deionized water, and use absolute ethanol to ultrasonic 10- After 20 minutes, wipe dry with a paper towel after ultrasonication, pickle in 90wt% phosphoric acid solution for 15 seconds, and finally wash with alkali in sodium hydroxide solution for 20 seconds, rinse with deionized water and dry in the air;

[0032] 2) Preparation of Ca 2+ Concentration is 0.2mol / L, EDTA-2Na concentration is 0.2mol / L, H 2 PO 4 - The concentration is 0.06mol / L, Zn 2+ A hydrothermal solution with a concentration of 0.005mol / L, adjusted to pH=9 by sodium hydroxide, wherein the calcium source is calcium nitrate tetrahydrate, the phosphorus source is sodium dihydrogen phosphate dihydrate, and the zinc source is zinc nitrate;

[0033]3) Place the magnesium alloy...

Embodiment 2

[0037] 1) Wire-cut the magnesium alloy substrate into a suitable size, and then polish it with 600#, 1500#, 2000# silicon carbide water-resistant sandpaper to remove the oxide layer on the surface of the magnesium alloy, then rinse it with deionized water, and use absolute ethanol to ultrasonic 10- After 20 minutes, wipe dry with a paper towel after ultrasonication, pickle in 90wt% phosphoric acid solution for 15 seconds, and finally wash with alkali in sodium hydroxide solution for 20 seconds, rinse with deionized water and dry in the air;

[0038] 2) Preparation of Ca 2+ Concentration is 0.2mol / L, EDTA-2Na concentration is 0.2mol / L, H 2 PO 4 - The concentration is 0.06mol / L, Zn 2+ A hydrothermal solution with a concentration of 0.005mol / L, adjusted to pH=9 by sodium hydroxide, wherein the calcium source is calcium nitrate tetrahydrate, the phosphorus source is sodium dihydrogen phosphate dihydrate, and the zinc source is zinc nitrate;

[0039] 3) Place the magnesium allo...

Embodiment 3

[0042] 1) Wire-cut the magnesium alloy substrate into a suitable size, and then polish it with 600#, 1500#, 2000# silicon carbide water-resistant sandpaper to remove the oxide layer on the surface of the magnesium alloy, then rinse it with deionized water, and use absolute ethanol to ultrasonic 10- After 20 minutes, wipe dry with a paper towel after ultrasonication, pickle in 90wt% phosphoric acid solution for 15 seconds, and finally wash with alkali in sodium hydroxide solution for 20 seconds, rinse with deionized water and dry in the air;

[0043] 2) Preparation of Ca 2+ Concentration is 0.2mol / L, EDTA-2Na concentration is 0.2mol / L, H 2 PO 4 - The concentration is 0.06mol / L, Zn 2+ A hydrothermal solution with a concentration of 0.005mol / L, adjusted to pH=10 by sodium hydroxide, wherein the calcium source is calcium nitrate tetrahydrate, the phosphorus source is sodium dihydrogen phosphate dihydrate, and the zinc source is zinc nitrate;

[0044] 3) Place the magnesium all...

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Abstract

The invention relates to a preparation method of a zinc-doped hydroxyapatite coating used for a magnesium alloy material. The method comprises the following steps of (1) pretreatment of a magnesium alloy matrix, specifically, after being cut and ground, the magnesium alloy matrix is washed to be clean; (2) preparation of hydrothermal solution, specifically, a calcium source, a phosphorus source and a zinc source are added into water, the pH value is regulated to be 9-11, and the hydrothermal solution is obtained; and (3) preparation of the coating, specifically, the magnesium alloy matrix after pretreatment is placed a hydrothermal reactor containing the hydrothermal solution, the hydrothermal reaction is conducted, and the zinc-doped hydroxyapatite coating wrapping the magnesium alloy matrix is obtained. Compared with the prior art, the preparation method adopts a hydrothermal method to prepare the zinc-doped modified hydroxyapatite coating on the surface of a magnesium alloy, the coating is uniform and compact, combining of the coating and the matrix is good, the thickness of a film layer is considerable, and the biocompatibility of the magnesium alloy is further improved while the corrosion resistance of the magnesium alloy is improved effectively.

Description

technical field [0001] The invention belongs to the technical field of biological materials, and relates to a preparation method of a zinc-doped hydroxyapatite coating for magnesium alloy materials. Background technique [0002] In recent years, magnesium and magnesium alloys have gradually become a class of biomedical degradable metal materials with great potential in this century. Compared with existing bone repair materials, the elastic modulus (about 45GPa) of magnesium alloy is closest to that of human bone tissue (3-20GPa), which can reduce the stress shielding problem after implantation of traditional materials and avoid bone healing Sudden exposure to excessive stimulation can cause bone loosening or re-fracture. Magnesium is naturally degradable and absorbable, so that the magnesium alloy material can be degraded spontaneously in the human body, avoiding secondary surgery, reducing the pain of patients, and also avoiding the long-term impact of implant materials on...

Claims

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Application Information

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IPC IPC(8): C23C18/12A61L27/04A61L27/32A61L27/50
CPCA61L27/047A61L27/32A61L27/50A61L2400/18A61L2420/02A61L2420/06A61L2430/02C23C18/1204C23C18/1241
Inventor 陆伟马尚军向震王韬磊钱立伟罗振益
Owner TONGJI UNIV
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