Medical sponge
A sponge and microsphere technology, applied in the field of medical sponges, can solve the problems of incomplete function and loss of activity, and achieve the effects of protecting wound healing, good bacteriostatic effect, and strong absorbency
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Embodiment 1
[0025] This embodiment provides a medical sponge, such as figure 1 , comprising a chitosan cushion layer 1, a water-absorbing layer 2 and a bacteriostatic surface layer 3, the chitosan cushion layer is composed of a chitosan film layer 4 and is compounded in the chitosan film layer and loaded with components It consists of gelatin microspheres of fibroblast growth factor 5, the antibacterial surface layer is a modified activated carbon fiber layer, and the water-absorbing layer is an alginate layer.
[0026] The preparation method of described chitosan cushion layer, comprises the steps:
[0027] (1) First soak the gelatin with an appropriate amount of distilled water until it swells, then continue to add distilled water and stir until it is completely dissolved to obtain a gelatin solution; add 0.3g of gelatin to every 1mL of distilled water;
[0028] (2) Add Span 80 into liquid paraffin, stir evenly to obtain solution A, then add gelatin solution to solution A, heat and sti...
Embodiment 2
[0035] This embodiment provides a medical sponge, such as figure 1 , comprising a chitosan cushion layer 1, a water-absorbing layer 2 and a bacteriostatic surface layer 3, the chitosan cushion layer is composed of a chitosan film layer 4 and is compounded in the chitosan film layer and loaded with components It consists of gelatin microspheres of fibroblast growth factor 5, the antibacterial surface layer is a modified activated carbon fiber layer, and the water-absorbing layer is an alginate layer.
[0036] The preparation method of described chitosan cushion layer, comprises the steps:
[0037] (1) First soak the gelatin with an appropriate amount of distilled water until it swells, then continue to add distilled water and stir until it is completely dissolved to obtain a gelatin solution; add 0.3g of gelatin to every 1mL of distilled water;
[0038] (2) Add Span 80 into liquid paraffin, stir evenly to obtain solution A, then add gelatin solution to solution A, heat and sti...
experiment example
[0045] One, take the medical sponge of embodiment 1, the medical sponge of embodiment 2 and the commercially available medical sponge as samples, and evaluate the treatment of full-thickness skin defect wounds on the back of rats
[0046] Select 60 healthy rats with a body weight of 180-220 g, inject 3% pentobarbital sodium (30 mg / kg) in their intraperitoneal cavity, and divide them into 3 groups randomly, 20 rats in each group. Two 2.0cm*2.0cm wounds were cut on both sides of the middle part of the rat's back spine, and a little muscle tissue was destroyed, and the bleeding was stopped for later use.
[0047] The sample was applied to the wound, and the dressing was changed the next day. On the 2nd day, 5th day and 10th day after the wound surface was made, take photos to record the wound surface healing situation, and use the image analysis software Imagepro-Plus to measure the wound surface area, and calculate the wound healing rate of the full-thickness skin defect on the ...
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