Medical sponge

A sponge and microsphere technology, applied in the field of medical sponges, can solve the problems of incomplete function and loss of activity, and achieve the effects of protecting wound healing, good bacteriostatic effect, and strong absorbency

Active Publication Date: 2018-05-18
广州倍健医疗用品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when the growth factor is applied to a local wound, it will be quickly degraded by the enzymes produced at the wound and lose its activity, so that it cannot fully function

Method used

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] This embodiment provides a medical sponge, such as figure 1 , comprising a chitosan cushion layer 1, a water-absorbing layer 2 and a bacteriostatic surface layer 3, the chitosan cushion layer is composed of a chitosan film layer 4 and is compounded in the chitosan film layer and loaded with components It consists of gelatin microspheres of fibroblast growth factor 5, the antibacterial surface layer is a modified activated carbon fiber layer, and the water-absorbing layer is an alginate layer.

[0026] The preparation method of described chitosan cushion layer, comprises the steps:

[0027] (1) First soak the gelatin with an appropriate amount of distilled water until it swells, then continue to add distilled water and stir until it is completely dissolved to obtain a gelatin solution; add 0.3g of gelatin to every 1mL of distilled water;

[0028] (2) Add Span 80 into liquid paraffin, stir evenly to obtain solution A, then add gelatin solution to solution A, heat and sti...

Embodiment 2

[0035] This embodiment provides a medical sponge, such as figure 1 , comprising a chitosan cushion layer 1, a water-absorbing layer 2 and a bacteriostatic surface layer 3, the chitosan cushion layer is composed of a chitosan film layer 4 and is compounded in the chitosan film layer and loaded with components It consists of gelatin microspheres of fibroblast growth factor 5, the antibacterial surface layer is a modified activated carbon fiber layer, and the water-absorbing layer is an alginate layer.

[0036] The preparation method of described chitosan cushion layer, comprises the steps:

[0037] (1) First soak the gelatin with an appropriate amount of distilled water until it swells, then continue to add distilled water and stir until it is completely dissolved to obtain a gelatin solution; add 0.3g of gelatin to every 1mL of distilled water;

[0038] (2) Add Span 80 into liquid paraffin, stir evenly to obtain solution A, then add gelatin solution to solution A, heat and sti...

experiment example

[0045] One, take the medical sponge of embodiment 1, the medical sponge of embodiment 2 and the commercially available medical sponge as samples, and evaluate the treatment of full-thickness skin defect wounds on the back of rats

[0046] Select 60 healthy rats with a body weight of 180-220 g, inject 3% pentobarbital sodium (30 mg / kg) in their intraperitoneal cavity, and divide them into 3 groups randomly, 20 rats in each group. Two 2.0cm*2.0cm wounds were cut on both sides of the middle part of the rat's back spine, and a little muscle tissue was destroyed, and the bleeding was stopped for later use.

[0047] The sample was applied to the wound, and the dressing was changed the next day. On the 2nd day, 5th day and 10th day after the wound surface was made, take photos to record the wound surface healing situation, and use the image analysis software Imagepro-Plus to measure the wound surface area, and calculate the wound healing rate of the full-thickness skin defect on the ...

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Abstract

The invention discloses a medical sponge which comprises a chitosan application cushion layer, a water absorption layer and an anti-bacteria surface layer; the chitosan application cushion layer is composed of a chitosan film layer and gelatin microspheres composited into the chitosan film layer and loaded with fibroblast growth factors, and the anti-bacteria surface layer is a modified activatedcarbon fiber layer; the chitosan application cushion layer has the good histocompatibility and degradability, the fibroblast growth factors can be slowly released, and tissue growth and wound healingare promoted; the water absorption layer has the high absorptivity, percolate of a wound can be rapidly absorbed, and wound surface inflammations are reduced; the anti-bacteria surface layer can adsorb peculiar smell of medicine and the wound, the good anti-bacteria effect is achieved, the phenomenon that the wound is affected by bacteria in the external environment can be avoided, and wound healing is further protected. The medical sponge is convenient to use, medicine does not need to be replaced frequently, no stimulation or toxic or side effect is caused to skin, the wound can be protectedagainst infection, and the wound inflammations can be reduced.

Description

technical field [0001] The invention relates to a wound dressing, in particular to a medical sponge with slow-release function. Background technique [0002] The healing of skin wounds can be roughly divided into hemostatic phase, inflammation phase, hyperplasia of granulation tissue, and scar formation. Traditional dressings have low drug delivery efficiency, require frequent dressing changes, are irritating to the skin, have a long treatment period, are prone to infection, and are not suitable for patients to tolerate. In order to reduce adverse reactions and the frequency of administration, and meet the requirements of high efficiency, long-term effect, and low toxicity and side effects, drug sustained-release dressings can be used. Drug sustained-release dressings can effectively promote and improve wound healing by slowly releasing drugs to prevent wound infection, reduce inflammation, promote granulation tissue formation, affect local epithelial regeneration, and bala...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/18A61L15/42A61L15/44A61L15/46A61L15/62
CPCA61L15/18A61L15/28A61L15/425A61L15/44A61L15/46A61L15/62A61L2300/414A61L2300/604A61L2300/622C08L5/08C08L5/04
Inventor 车七石
Owner 广州倍健医疗用品有限公司
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