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Saliva acid derivative and preparing method and application thereof

A technology of sialic acid derivatives and preparation steps, applied in the field of biomedicine, can solve the problems of low affinity of sialic acid, difficulty in CD169+ macrophages to exert anti-tumor function, etc.

Active Publication Date: 2018-05-18
XIAMEN NUOKANGDE BIOLOGICAL TECH CO LTD
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  • Abstract
  • Description
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Problems solved by technology

[0008] SIGLEC-1 has the ability to specifically bind sialic acid, but its affinity for sialic acid is not high. Therefore, it is difficult for CD169+ macrophages to exert anti-tumor function in tumor immune response. How to improve the affinity of CD169 for sialic acid and stimulate CD169+ macrophages The tumor-killing function of the

Method used

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  • Saliva acid derivative and preparing method and application thereof
  • Saliva acid derivative and preparing method and application thereof
  • Saliva acid derivative and preparing method and application thereof

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Embodiment Construction

[0044]In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments It is a part of embodiments of the present invention, but not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0045] The chemical formula of the sialic acid derivative provided by the invention is:

[0046]

[0047] The sialic acid derivative provided by the present invention is a 9-substituent derivative (TCC-Neu5Gc) of N-acetylneuraminic acid monosaccharide, and its specific synthetic route is as follows:

[0048]

[0049] The concrete synthe...

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Abstract

The invention provides a saliva acid derivative and a preparing method and application thereof. The saliva acid derivative is a small-molecular anti-tumor compound (TCC-Neu5Gc) and can kill tumors through the specific and broad-spectrum properties of the derivative. The TCC-Neu5Gc targets in-vivo tumors and grows on surfaces of tumor cells through metabolism to form TCC-Neu5Gc ligands. The TCC-Neu5Gc ligands are recognized and then phagocytized by macrophages near the tumors, meanwhile tumor fragments are released and transmitted to other immune cells, and the anti-tumor immune reaction is initiated. The saliva acid derivative is effective for various tumors and also has a restraining effect on tumor metastasis. In addition, the saliva acid derivative can be injected and can also be orallytaken to come into play, is low in cytotoxicity and animal toxicity, and has quite high medicinal value and wide application prospects.

Description

technical field [0001] The invention relates to the field of biomedical technology, in particular to a sialic acid derivative and its preparation method and application. Background technique [0002] Sialic acid is N-acetylneuraminic acid or any of its esters or derivatives of its alcoholic hydroxyl group. It is located at the end of the side chain of the cell membrane glycoprotein and is an important part of the cell membrane surface receptor. It is involved in various inflammatory diseases and malignant tumors. When the amount and concentration will increase, such as lung cancer, gastric cancer, intestinal cancer, liver cancer, ovarian cancer and other diseases. [0003] Traditional cancer treatment methods include surgery, radiotherapy and chemotherapy, but none of these methods can effectively eliminate cancer. After entering the 21st century, with the in-depth development of oncology and immunology, tumor immunotherapy emerged as the latest and most advanced therapy. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H13/04C07H1/00C07H1/06A61P35/00
CPCC07H1/00C07H1/06C07H13/04
Inventor 李柱闫旭韩绪春郭岗黄国锋
Owner XIAMEN NUOKANGDE BIOLOGICAL TECH CO LTD
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