Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Vaccine, vaccine emulsification process and application

A technology for vaccines and inactivated vaccines, applied in vaccines, vaccine emulsification technology and application fields, can solve problems such as uneven composition, poor viscosity and stability, unstable vaccine quality, etc., achieve uniform composition and performance, and reduce equipment requirements , the effect of improving the immune effect

Active Publication Date: 2022-04-26
天康生物制药有限公司
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The first object of the present invention is to provide a vaccine emulsification process to alleviate the technical problems in the prior art that the product components are not uniform after emulsification, the viscosity and stability are poor, and the immune effect of the prepared vaccine is not ideal.
[0007] The second purpose of the present invention is to provide a vaccine to alleviate the technical problems of unstable vaccine quality and unsatisfactory immune effect in the prior art

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] This embodiment provides a vaccine emulsification process, comprising the following steps:

[0047] Step a): filter the 206 adjuvant with a nylon filter membrane at 18°C, and heat the adjuvant to 32°C after filtration;

[0048] Step b): adding the 2°C foot-and-mouth disease inactivated vaccine antigen dropwise into the adjuvant, and the temperature of the adjuvant is always maintained at 32°C;

[0049] Step c): after the dropwise addition, the stirring was continued, and the temperature was lowered to 2° C., and the emulsified inactivated foot-and-mouth disease vaccine was prepared.

Embodiment 2

[0051] This embodiment provides a vaccine emulsification process, comprising the following steps:

[0052] Step a): filter the 206 adjuvant with PVDF membrane at 25°C, and heat the adjuvant to 34°C after filtration;

[0053] Step b): adding the 8°C foot-and-mouth disease inactivated vaccine antigen dropwise into the adjuvant, and the temperature of the adjuvant is always maintained at 34°C;

[0054] Step c): After the dropwise addition, the stirring was continued, and the temperature was lowered to 8° C. to prepare the emulsified inactivated foot-and-mouth disease vaccine.

Embodiment 3

[0056] This embodiment provides a vaccine emulsification process, comprising the following steps:

[0057] Step a): at 22°C, filter the 206 adjuvant with a tetrafluoroethylene filter membrane, and heat the adjuvant to 35°C after filtration;

[0058] Step b): adding the 6°C foot-and-mouth disease inactivated vaccine antigen dropwise into the adjuvant, and the temperature of the adjuvant is always maintained at 35°C;

[0059] Step c): After the dropwise addition, the stirring was continued, and the temperature was lowered to 6° C. to prepare the emulsified inactivated foot-and-mouth disease vaccine.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
pore sizeaaaaaaaaaa
porosityaaaaaaaaaa
Login to View More

Abstract

The invention relates to the field of vaccine processing, in particular, it provides a vaccine, a vaccine emulsification process and its application. In the vaccine emulsification process provided by the invention, the antigen is added dropwise to the adjuvant filtered and sterilized by a filter sterilizer to prepare the emulsified vaccine. The sterilization treatment of the adjuvant uses the filtration sterilization process instead of the traditional high-temperature sterilization method. This method is simple and easy to operate, and the prepared product has uniform composition and performance, good stability, and significantly improved immune effect. The vaccine provided by the invention is prepared by applying the emulsification process of the above-mentioned vaccine. The composition and performance of the vaccine are uniform, the stability is good, the immune effect is significantly improved, and the vaccine can be industrialized and applied in production and life.

Description

technical field [0001] The invention relates to the field of vaccine processing, in particular to a vaccine, an emulsification process and application of the vaccine. Background technique [0002] Biological products such as vaccines are an important means for humans to fight against viral diseases, and the safety and quality stability of vaccine production are getting more and more attention. Some vaccine production processes include medium preparation, cell cultivation, mixing, buffer preparation, terminal filtration and other processes, followed by processes such as emulsification, sub-packaging, and finished product inspection. Among them, emulsification is a key step in vaccine production, and the quality of the emulsification process directly determines the quality of the vaccine. [0003] The process and technical conditions of oil, emulsifier, and water from the initial entry into the production equipment to the output of the finished emulsion are usually called the...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K39/135A61P31/14A61L2/02
CPCA61K39/12A61L2/02C12N2770/32134A61L2202/21A61K2039/5252
Inventor 廖勇王涛刘苡佑唐磊邹鲁张忠
Owner 天康生物制药有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com