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Application of kinsenoside in preparation of drug for treating insulin resistance

A technology for insulin resistance and clematis glycosides is applied in the directions of drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, which can solve problems such as unclear molecular mechanisms, improve insulin resistance and type 2 diabetes, and increase intake. Effect

Inactive Publication Date: 2018-06-15
SHENZHEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the molecular mechanism behind it is still unclear, so it still needs to be further improved and developed.

Method used

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  • Application of kinsenoside in preparation of drug for treating insulin resistance
  • Application of kinsenoside in preparation of drug for treating insulin resistance
  • Application of kinsenoside in preparation of drug for treating insulin resistance

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Embodiment Construction

[0018] The present invention provides the application of aureoside in the preparation of medicines for treating insulin resistance or type 2 diabetes. In order to make the purpose, technical scheme and effect of the present invention clearer and clearer, the present invention will be further described in detail below. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0019] In the present invention, using rat skeletal muscle cells as a model, in the case of insulin sensitivity and insulin resistance, the activation of protein kinases Akt and AMPK by auroside was detected by Western blot method, and fluorescently labeled 2-deoxy Glucose is an energy substrate to detect the uptake of glucose by cells before and after treatment with auroglucoside. The results showed that in normal cells, auroside can significantly increase the activity of Akt and AMPK and promote the uptake of...

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Abstract

The invention discloses application of kinsenoside in the preparation of a drug for treating insulin resistance. According to the application, a rat skeletal muscle cell is used as a model to study the promoting effect of the kinsenoside on glucose uptake by cells under normal and insulin resistance conditions. Results show that the kinsenoside can increase glucose uptake by the cells by means ofactivation of Akt and AMPK, so that the situation of insulin resistance is improved.

Description

technical field [0001] The invention relates to the technical field of medical applications, in particular to the application of auroside in the preparation of medicines for treating insulin resistance or type 2 diabetes. Background technique [0002] With the improvement of living standards, more and more people suffer from obesity, metabolic syndrome, heart disease and type 2 diabetes, and the mechanisms of these diseases are all related to insulin resistance (Insulin Resistance, IR). The accumulation of fatty acids and triglycerides in skeletal muscle cells in type 2 diabetes leads to decreased sensitivity of skeletal muscles to insulin, which is an important cause of insulin resistance. Under insulin stimulation, more than 70% of glucose in the body can be taken up and utilized by skeletal muscle cells, so skeletal muscle is the most important tissue for taking up glucose. Insulin is mainly metabolically regulated through the phosphatidylinositol 3-kinase (PI3K) signali...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P5/50A61P3/10
CPCA61K31/7048
Inventor 贺震旦吴序栎
Owner SHENZHEN UNIV