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Medicine composition for preventing and controlling AD (Alzheimer Disease)

A technology for Alzheimer's disease, composition, applied in the field of medicine

Inactive Publication Date: 2018-06-29
ACADEMY OF MILITARY MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the current shortage of drugs that can effectively prevent and treat AD, the present invention provides compounds or compositions for preventing and treating Alzheimer's disease

Method used

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  • Medicine composition for preventing and controlling AD (Alzheimer Disease)
  • Medicine composition for preventing and controlling AD (Alzheimer Disease)
  • Medicine composition for preventing and controlling AD (Alzheimer Disease)

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The preparation of embodiment 1 sodium rutin

[0025] At room temperature, the solubility of rutin in water is about 0.13mg / ml.

[0026] At room temperature, dissolve rutin with 100mM NaOH aqueous solution, the solubility exceeds 20mg / ml, which is about 200 times higher than the original, and then titrate with hydrochloric acid, titrate the pH value to about 9, and get the pH value titrated to about 9, about 20mg / ml of sodium rutin aqueous solution ( figure 1 ).

[0027] In order to identify the structure of rutin sodium, the remaining alkali and generated salt in the aqueous solution of rutin sodium were removed by MCI column (MCI GEL CHP20p), washed with double distilled water, eluted with methanol, concentrated and evaporated to dryness to obtain rutin sodium deep brown solid. Dissolve solid sodium rutin in CD 3 OD (0.5mg / ml) and by nuclear magnetic detection (DD2500MHz), such as figure 2 As shown, through comparative analysis with normal rutin, it is found th...

Embodiment 2

[0028] Example 2 mouse model verification of the prevention and treatment effect of rutin sodium on AD

[0029] APP / PS1 transgenic mice and 5XFAD transgenic mice were used as models respectively.

[0030] APP / PS1 transgenic mice are a chronic AD model, administered (rutin sodium stock solution diluted to 0.25 mg / ml with the normal drinking water of mice) before the onset of the mice (6 months), and administered continuously for 6 months, The spatial learning and memory ability of mice was tested with water maze, and the early preventive effect of sodium rutin (NaR) on AD was simulated. Blank control group: the blank control group is normal drinking water control.

[0031] 5XFAD transgenic mice are an acute AD model, and the pathological features appear in the mice after two or three months. The mice were given drugs when they were 4 months old, and the drugs were given continuously for three months. The spatial learning and memory ability of mice was tested by water maze, an...

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Abstract

The invention discloses a medicine composition for preventing and controlling AD (Alzheimer Disease), and belongs to the field of medicines. The medicine composition has the advantages that the watermaze experiment is performed by an APP / PS1 (amyloid precursor protein / presenilin 1) transgenic mouse (chronic AD model) and a 5XFAD transgenic mouse (acute AD model), and the function of the compoundshown in formula II for improving the space learning and memory abilities of the two mouse is verified; the obvious preventing and treatment function of rutin or derivative of rutin on AD is realized.

Description

technical field [0001] The invention relates to a pharmaceutical composition for preventing and treating Alzheimer's disease, which belongs to the field of medicine. Background technique [0002] Alzheimer's disease (AD), commonly known as senile dementia, is a neurodegenerative disease characterized by progressive cognitive dysfunction and impairment of learning and memory. Among dementia diseases, AD is the most important disease type. According to demographic forecasts, by 2050, the number of AD patients worldwide will exceed 100 million, which will greatly reduce the quality of life of the relevant population and increase the burden on the entire society. Due to the complexity of AD, its pathogenesis is still unclear, and there is no effective treatment in clinical practice. Therefore, the development of effective drugs for the prevention and treatment of AD is still an urgent problem to be solved. [0003] In current clinical trials, many antibody drugs targeting the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048C07H17/07A61P25/28
Inventor 袁增强程金波潘瑞远
Owner ACADEMY OF MILITARY MEDICAL SCI
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