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T-type endotracheal intubation with antibacterial and lubricating functions for medical use and preparation method thereof

A technology for endotracheal intubation and function, applied in the direction of endotracheal intubation, medical formula, catheter, etc., can solve the problems of few explorations, achieve the effect of prolonging the antibacterial cycle, suitable for large-scale application, and good hydrophilic lubrication effect

Inactive Publication Date: 2018-06-29
上海士宇生物技术有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This material has been used in the research of antibacterial coating modification of medical materials, but how to achieve it in the safest way and preserve the surface of medical materials for a long time is still not much exploration

Method used

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  • T-type endotracheal intubation with antibacterial and lubricating functions for medical use and preparation method thereof
  • T-type endotracheal intubation with antibacterial and lubricating functions for medical use and preparation method thereof
  • T-type endotracheal intubation with antibacterial and lubricating functions for medical use and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1: Seal both ends of the silicone rubber T-shaped tracheal intubation tube, put it into 500ml of 50% ethanol solution for ultrasonic cleaning for 20 minutes, then use high-purity water for ultrasonic cleaning to remove all impurities on the surface of the intubation tube, and then place it in a temperature-controlled drying oven Dry at 40°C for later use.

Embodiment 2

[0019] Example 2: Add 10ml of 2-aminoethyl-aminopropyltrimethoxysilane to 50ml of 25% ethanol solution, adjust the pH value of the solution with a small amount of glacial acetic acid, and let it stand until the coupling agent solution is completely clear. The cleaned T-shaped endotracheal tube in Example 1 was soaked in the connecting coating solution, slowly pulled out of the liquid surface after 60 seconds, repeated treatment for 3 to 5 times, and dried with a hot air blower to complete the tube of the silane coupling agent. Wall coating.

Embodiment 3

[0020] Example 3: Weigh 50mg of water-soluble O-carboxymethyl chitosan with a molecular weight of 35KD, stir and dissolve in 500ml of acetic acid-sodium acetate buffer solution (PH=5.5), add N,N-dicyclohexylcarbodiene imine (DCC) to a concentration of 10 mM. Slowly put the T-shaped endotracheal tube coated with silane coupling agent in Example 2, let it stand overnight at 4°C, take it out and rinse it with deionized water several times to obtain a T-shaped endotracheal tube coupled with chitosan on the surface intubation.

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Abstract

The invention discloses a T-type endotracheal intubation with antibacterial and lubricating functions for medical. Carboxymethyl chitosan is connected to the surface of the endotracheal intubation withsilane coupling agent to form a surface antibacterial coating, then the surface antibacterial coating further crosslinks hydrophilic material poly-(2-ethyl-2- oxazoline), and the T-type endotrachealintubation with the antibacterial and lubricating functions is prepared. The T-type endotracheal intubation with antibacterial and lubricating functions can reduce the airway damage to the larynx of apatient during placement, is suitable for reducing the risk of bacterial infection caused by long-term intention of the intubation in the airway, and improving the therapeutic compliance of the patient with the endotracheal intubation.

Description

technical field [0001] The invention relates to a medical tracheal intubation tube with anti-bacteria lubrication function, specifically a T-shaped tracheal intubation tube modified with chitosan and hydrophilic material coating and a preparation method thereof Background technique [0002] At present, most medical laryngeal tracheotomy tubes are made of hydrophobic silicone rubber materials. Although it has excellent mechanical properties and biocompatibility, as a hydrophobic material, it has a large friction force on tissues when it is inserted into the human body. It is easy to damage the laryngeal airway, blood vessel wall and other epithelial tissues, causing pain or burning sensation, and it is easy to absorb bacteria and cause concurrent inflammation, especially during the insertion and removal of the intubation process, which will bring significant pain and damage to the patient. [0003] The surface of medical hydrophobic materials is modified by adding hydrophilic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M16/04A61L29/08A61L29/16
CPCA61L29/085A61L29/16A61L2300/232A61L2300/404A61L2300/45A61L2300/602A61L2300/606A61L2400/10A61L2400/18A61L2420/02A61L2420/06A61L2420/08A61M16/04C08L5/08
Inventor 陈怀文郑宏良杨冬梅张才云陈东辉陈世彩朱敏辉高颖娜董银梅李孟贺智明王凤英
Owner 上海士宇生物技术有限公司
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