Schiff alkali ligand of ruthenium, preparation method and application thereof

Abstract

The invention discloses a Schiff alkali ligand for ruthenium, a preparation method and application thereof. The preparation method comprises the following steps: heating and dissolving ruthenium saltwith stirring in a mixed solvent to obtain a solution 1; heating and dissolving the Schiff alkali ligand in the mixed solvent to obtain a solution 2, stopping the heating on the solution 2, and cooling the solution 2 to room temperature, adding the solution 1 into the solution 2 to obtain a solution 3; continually stirring the solution 3 at room temperature for 0.5 to 1.0h, standing the solution 3in a high-pressure reaction kettle, heating and cooling the solution 3 through program control to obtain a Schiff alkali ligand of the ruthenium being of a brick-red crystal appearance. The Schiff alkali ligand of ruthenium provided by the invention has the advantages of high crystal form stability, relative simple preparation method and post treatment manner, capability of being applied to the tumor activity resistant aspect and remarkable tumor resistance, as well as is taken as an important basis for the subsequent researching of the anti-tumor medicines.

Description

technical field [0001] The invention belongs to the technical field of anticancer drugs, in particular to a Schiff base complex of ruthenium and its preparation method and application. Background technique [0002] Cisplatin is a commonly used drug for the treatment of cancer. Its anti-tumor mechanism mainly uses DNA as the main target, destroys DNA replication and inhibits cell division to inhibit the growth of tumor cells. However, the long-term use of cisplatin drugs has the disadvantages of large toxic and side effects, strong drug resistance and narrow anticancer spectrum. [0003] However, the development of metal complexes represented by cisplatin has successfully promoted the development and research of anticancer drugs, and promoted the development of metal complexes in the entire medical field. Metal complexes, especially some Schiff base metal complexes, because these compounds contain functional functional groups, have some physical and chemical properties requi...

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Problems solved by technology

In recent years, there have been some reports on the antitumor activity of Schiff base complexes, but there are few reports on the effect of complexes formed by platinum metals and Schiff base compounds on tumor cells.

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