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Inducer of intervertebral disc cell autophagy

A technology of autophagy and inducers, applied in the direction of vertebrate cells, animal cells, artificial cell constructs, etc., can solve the problem of unsatisfactory induction of autophagy in intervertebral disc cells, unclear pathogenesis of intervertebral disc degeneration, and loss of work ability of patients and other problems, to achieve the effect of stable induction effect, increase the success rate of experiments, and save experiment time

Active Publication Date: 2018-07-06
暨赛国际再生医学科技有限公司
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  • Summary
  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

Severe low back pain can make patients incapable of work and impose a heavy burden on society and families
More than 40% of low back pain is caused by intervertebral disc degeneration, but the exact pathogenesis of intervertebral disc degeneration is still unclear
When the applicant of the present invention was studying the effect of autophagy on intervertebral disc degeneration, it was found that the autophagy induction effect of rapamycin alone on intervertebral disc cells was not satisfactory and the induction effect was unstable, which seriously hindered the research progress in this field

Method used

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  • Inducer of intervertebral disc cell autophagy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] An inducer of autophagy in intervertebral disc cells, the inducer is a final concentration of 50nM rapamycin, 50mM lithium chloride and 100μM nickel sulfate.

Embodiment 2

[0029] An inducer of autophagy in intervertebral disc cells, the inducer is a final concentration of 400nM rapamycin, 5mM lithium chloride and 1000μM nickel sulfate.

Embodiment 3

[0031] An inducer of autophagy in intervertebral disc cells, the inducer is a final concentration of 150nM rapamycin, 15mM lithium chloride and 250μM nickel sulfate.

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Abstract

The invention relates to the field of cell autophagy, in particular to an inducer for inducing intervertebral disc cell autophagy. The inducer of the intervertebral disc cell autophagy comprises rapamycin, lithium chloride and nickel sulfate. The inducer has high inducing success rate of the intervertebral disc cell autophagy and is stable in inducing effect; compared with the traditional inducer,an induced autophagy level is significantly raised; an experiment success rate of technicians in the art is greatly increased; and the experiment time is saved.

Description

technical field [0001] The invention relates to the field of cell autophagy, and more specifically relates to an inducer for inducing autophagy of intervertebral disc cells. Background technique [0002] Low back pain is a common disease in orthopedics. According to statistics from some researchers, more than half of people will suffer from low back pain in their lifetime. Severe low back pain can make patients incapable of work and impose a heavy burden on society and families. More than 40% of low back pain is caused by intervertebral disc degeneration, but the exact pathogenesis of intervertebral disc degeneration is still unclear. The research on the mechanism of intervertebral disc degeneration has focused on the changes of morphology and biochemistry in the past. It is believed that the changes in the structure of the intervertebral disc are caused by abnormal biomechanics, or the disorder of cell metabolism caused by nutritional dysfunction, which eventually leads to...

Claims

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Application Information

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IPC IPC(8): C12N5/071A61K33/24A61P19/08A61K31/436A61K33/14
CPCA61K31/436A61K33/14A61K33/24C12N5/0602C12N2500/05C12N2500/30A61K2300/00
Inventor 徐家科朱思品吴琨徐丽婉
Owner 暨赛国际再生医学科技有限公司
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