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Oral care gel

A gel, oral technology, used in oral care, dentistry, cosmetic preparations, etc., can solve the problems of weak bleaching efficiency, insufficient decomposition of complexes, etc.

Active Publication Date: 2018-07-17
COLGATE PALMOLIVE CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A second difficulty lies in the development of formulations that have the desired viscoelastic properties and also maintain long enough long-lasting activity against the hydrogen peroxide active ingredient
However, the disadvantage of this method is that in order for the hydrogen peroxide to be released to exert its bleaching effect on the teeth, water must be allowed to enter the preparation applied on the teeth
For highly hydrophobic formulations, water does not easily penetrate the gel, and due to PVP-H 2 o 2 Insufficient breakdown of the complex, which results in weak bleaching efficiency

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0104] Example 1 - Gel Formulation Optimization

[0105] Different gel formulations were prepared and tested to determine suitability for application with a pen dispenser. Many of the formulations tested were too thin or too thick to be used with a pen dispenser. Three formulations with potentially acceptable rheological properties based on initial visual evaluation and testing with a pen dispenser were selected for more detailed evaluation. Formulations A, B and C were prepared according to the table below (ingredients are % by weight of the total formulation).

[0106]

[0107]

[0108] The formulations were compared with respect to suitability for the intended use, the formulations were tested in two different pen dispenser types, one with a deer foot tip and the other with a brush tip. The results are summarized in the table below:

[0109]

[0110] The composition of Formulation B appears to be the most suitable for this application. The key difference betwee...

example 2

[0115] Example 2 - Bleaching Time

[0116]Commercial tooth whitening gel samples were prepared containing PVP-hydrogen peroxide as the bleaching agent, dimethicone and porous crosslinked polymer, each additionally containing 2% sodium tripolyphosphate and 0%, 0.05%, 0.15%, 0.50%, 1.0%, or 5.0% polysorbate-20. 0.5 g of each formulation was spread on a glass slide and smoothed. Eight drops of 1.7 mM Lissamine Green dye solution were added to the slide and the time it took to completely bleach 75% of the drop was recorded. The results are summarized in the table below:

[0117]

[0118] The results show that the addition of 0.05 to 5.0% by weight of polysorbate-20 results in a significant reduction in bleaching time. In addition, it was observed that as the concentration of polysorbate-20 increased, the wetting angle of the droplets increased. This suggests that polysorbate-20 increases the hydrophilicity of the composition, and without being bound by theory, it is believe...

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Abstract

The invention provides an orally acceptable tooth whitening gel wherein the gel comprises a hydrogen peroxide source, a silicone compound, a porous cross-linked polymer, and a nonionic surfactant, andexhibits a Herschel-Bulkley yield stress of 10 to 230 dynes / cm<2>, a Herschel-Bulkley viscosity of 3 to 500 poise, and a Herschel-Bulkley rate index of 0.4 to 0.6, the specific viscosity permitting efficient application of the gel, as well as methods of using the same.

Description

technical field [0001] The present invention relates to improved tooth whitening gels. Background technique [0002] Oral care compositions containing tooth whitening agents have been known for many years and include liquids, gels, tablets, mouthwashes, bars, trays, pens and other applicator devices. However, applying oral care products to teeth can cause difficulties. For example, application of these compositions can be messy because the whitening agent can drip into sensitive mucosal surfaces such as lips / gums and tongue where it can cause considerable irritation. Additionally, it can be difficult to apply whitening agents in a precise manner or to hard-to-reach portions of teeth. [0003] Hydrogen peroxide is a common whitening agent used in many existing tooth whitening devices, such as strips, trays, gels, and pens. It is an unstable compound and in the presence of water it slowly undergoes decomposition, losing its whitening power. Although tooth whitening pens ar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/22A61K8/86A61K8/81A61K8/89A61Q11/02
CPCA61Q11/02A61K8/8176A61K8/86A61K8/89A61K8/22A61K2800/872A61K8/042A61K8/60A61K8/8111A61K8/8182A61K2800/5422A61K2800/594A61Q11/00
Inventor 马哈茂德·哈桑劳伦·埃文斯
Owner COLGATE PALMOLIVE CO