Secreted splicing variant of mammal klotho as a medicament for cognition and behaviour impairments

Abstract

The invention discloses using secreted splicing variant of mammal Klotho (s- KL) as an agent for the prevention and / or treatment of cognitive and / or behaviour impairments. It also refers to gene constructs and expression vectors useful in gene therapy for the delivery of said s-KL variant to the central nervous system of a mammal, in particular a rodent or a human. Pharmaceutical compositions comprising either the protein s-KL or any gene construct for expressing the protein in the CNS are also disclosed.

Description

technical field

[0001] The present invention relates to the field of medical methods for the prevention and / or treatment of cognitive and behavioral disorders in patients suffering from diseases associated with memory loss and learning difficulties and / or neurodegenerative and / or neuropathological diseases. Background technique

[0002] It is well known that memories are often lost over time and that certain aspects may change resulting in a loss of memory efficiency. Examples of these include: difficulty maintaining attention on more than one thing at a time; difficulty learning new things that require effort; and slow retrieval of old information. Verbal ability, information processing, problem solving, working memory, long-term memory, spatial memory, and abilities decrease with age, while specialized knowledge and cognitive abilities such as semantic memory (vocabulary), world knowledge, and implicit memory are lost in the absence of Stable or even better with age in th...

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