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Traditional Chinese medicinal composition for treating proteinuria as well as preparation method and applications of traditional Chinese medicinal composition

A technology for treating proteins and compositions, which is applied in the direction of drug combinations, pharmaceutical formulas, hydrolyzed protein components, etc., can solve the problems of large side effects and unsatisfactory therapeutic effects of proteinuria diseases, and achieve good curative effect

Active Publication Date: 2018-07-20
上海复活石医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the above-mentioned shortcoming of the prior art, the object of the present invention is to provide a kind of Chinese medicine composition and its preparation method and application, be used to solve the disease treatment effect that causes proteinuria in the prior art unsatisfactory, the problem of big side effect

Method used

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  • Traditional Chinese medicinal composition for treating proteinuria as well as preparation method and applications of traditional Chinese medicinal composition
  • Traditional Chinese medicinal composition for treating proteinuria as well as preparation method and applications of traditional Chinese medicinal composition
  • Traditional Chinese medicinal composition for treating proteinuria as well as preparation method and applications of traditional Chinese medicinal composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Example 1: Preparation of Silkworm Cocoon Shell Polypeptide Extract

[0043]Take 1,000 grams of silkworm cocoon shells, cut them into pieces, add water to decoct 3 times, add 6 times the weight of water each time, decoct for 1.5 hours each time, filter, and combine the filtrates to obtain the cocoon shell filtrate; steam the cocoon shell filtrate Dilute it with water to a concentration equivalent to 5g / l00mL of silkworm cocoon shell medicinal materials, and then filter it with a microfiltration membrane with a pore size of 0.3 μm to obtain a microfiltrate; the microfiltrate is processed under a pressure of 0.2Mpa with an ultrafiltration membrane with a molecular weight cut-off of 15KD~25KD Ultrafiltration was performed, the retained liquid was discarded, and the obtained permeated liquid was combined, concentrated under reduced pressure, and freeze-dried to obtain 600 grams of silkworm cocoon shell active polypeptide extract.

Embodiment 2

[0044] Embodiment 2: the preparation of corn silk polysaccharide extract

[0045] Take 1,000 grams of corn silk, soak in water for 12 hours, heat and reflux for extraction for 3 hours; filter, and filter the filtrate through a 0.45 μm water membrane to collect the filtrate; Filter the medicinal solution of the membrane, concentrate, and dry to obtain 200 grams of corn silk polysaccharide extract.

Embodiment 3

[0046] Example 3: Comparative study of silkworm cocoon shell polypeptide extract and corn silk polysaccharide extract and their respective effects on proteinuria in diabetic nephropathy

[0047] The silkworm cocoon shell polypeptide extract and the corn silk polysaccharide extract prepared in Example 1 and Example 2 were used for experiments.

[0048] The SD rats were purchased and fed adaptively for 7 days. The blood sugar was normal, the urine protein qualitative test was negative, and the animals were in good health, and the experiment was started. According to body weight, they were randomly divided into two groups, namely blank control group (blank group) with 10 rats, and early model group with 50 rats. At the beginning of the experiment, the rats in each group were given a high-sugar and high-fat diet (20% sucrose, 10% lard, and 2.5% cholesterol were added to the conventional feed), while the blank control group had free access to ordinary feed, and both groups had free...

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Abstract

The invention provides a traditional Chinese medicinal composition for treating proteinuria as well as a preparation method and applications of the traditional Chinese medicinal composition. The traditional Chinese medicinal composition contains the following ingredients: silkworm cocoon shell polypeptide and corn stigma polysaccharide. The traditional Chinese medicinal composition provided by theinvention can effectively treat diseases causing proteinuria, and is free of toxic and side effects.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for treating proteinuria, a preparation method and application thereof, and belongs to the field of traditional Chinese medicines. Background technique [0002] Proteinuria is a common clinical manifestation and one of the earliest detectable indicators of urinary system diseases. Under normal circumstances, the urine protein of normal people is less than 150mg / d. When the kidney is diseased, the permeability of the glomerular filtration membrane increases, so that a large amount of protein is filtered into the glomerular filtrate, far exceeding the reabsorption of the renal tubules Ability, protein enters the final urine to cause proteinuria, which is more common in various primary or secondary glomerular diseases, renal circulation disorders, hypoxia and other diseases. Urinary protein can be small to more than 10g per day, mostly >2g / 24h, usually mainly albumin. When the renal ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/01A61P13/12A61P3/10A61K31/715
CPCA61K31/715A61K38/012A61K2300/00
Inventor 杨雪军杨涛
Owner 上海复活石医药科技有限公司
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