Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

n 6 Application of -(2-hydroxyethyl)adenosine and its derivatives in the preparation of gout medicines

A technology of hydroxyethyl and derivatives, which is applied in the field of medicine and can solve problems that have not been reported

Active Publication Date: 2022-07-26
ZHEJIANG SUB TROPICS CROP INST
View PDF14 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

N 6 -(2-Hydroxyethyl)adenosine (HEA) is an active compound isolated from Cordyceps cicadae. Although its anti-inflammatory and analgesic effects have also been reported, it has not been reported in the field of gout treatment

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • n <sup>6</sup> Application of -(2-hydroxyethyl)adenosine and its derivatives in the preparation of gout medicines
  • n <sup>6</sup> Application of -(2-hydroxyethyl)adenosine and its derivatives in the preparation of gout medicines
  • n <sup>6</sup> Application of -(2-hydroxyethyl)adenosine and its derivatives in the preparation of gout medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0056] The specific embodiment of the present invention is only used as a specific embodiment of the present invention to illustrate the direct proof of the new functions of the compounds mentioned in the present invention, but this is not a limitation of the present invention.

[0057] 1.. Materials used in specific embodiments of the present invention

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention provides N 6 Use of -(2-hydroxyethyl)adenosine in the treatment of gout. Cordyceps Extract N 6 ‑(2‑hydroxyethyl)adenosine has a good analgesic effect by activating adenosine A1 receptors. By giving gout rats N 6 ‑(2‑hydroxyethyl), 932 genes were differentially expressed in the joint synovium, of which 57 were pain-related genes and 12 were analgesia-related genes. N 6 ‑(2‑Hydroxyethyl)adenosine significantly reduced joint swelling, levels of interleukin 1β (IL‑1β) and tumor necrosis factor alpha (TNF‑α) in serum and joint washing fluid, and decreased NLRP3 inflammasome , the level of caspase-1 (caspase-1), and promote autophagy and p62 degradation, play an anti-inflammatory and analgesic effect. Can be used to relieve pain and inflammation caused by gout.

Description

technical field [0001] The invention relates to the technical field of medicine, and belongs to the application of an active substance extracted from Cordyceps fungus (or artificially synthesizing the active substance) for anti-inflammatory and analgesia in gout disease. Background technique [0002] Gout is a metabolic disease caused by the continuous increase of serum uric acid concentration leading to the deposition of urate crystals in soft tissues. The onset of gout is rapid, accompanied by red, swollen and hot pain, more than at night. The pain can wake people up from sleep. Most of the affected joints are the metatarsal toes or the thumb. In the early stage of the onset, there is usually a single arthritis, and local hyperalgesia occurs after a few hours. and limited activities, which can lead to disability later. Its incidence is increasing year by year to 1-2% and it is younger (So 2008), causing a huge burden to people's lives. Colchicine and non-steroidal anti-i...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07H19/167C07H1/08A61K31/7076A61P19/06
CPCC07H1/08C07H19/167
Inventor 柴一秋朱伟坚
Owner ZHEJIANG SUB TROPICS CROP INST
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com