n 6 Application of -(2-hydroxyethyl)adenosine and its derivatives in the preparation of gout medicines

Abstract

The present invention provides N 6 Use of -(2-hydroxyethyl)adenosine in the treatment of gout. Cordyceps Extract N 6 ‑(2‑hydroxyethyl)adenosine has a good analgesic effect by activating adenosine A1 receptors. By giving gout rats N 6 ‑(2‑hydroxyethyl), 932 genes were differentially expressed in the joint synovium, of which 57 were pain-related genes and 12 were analgesia-related genes. N 6 ‑(2‑Hydroxyethyl)adenosine significantly reduced joint swelling, levels of interleukin 1β (IL‑1β) and tumor necrosis factor alpha (TNF‑α) in serum and joint washing fluid, and decreased NLRP3 inflammasome , the level of caspase-1 (caspase-1), and promote autophagy and p62 degradation, play an anti-inflammatory and analgesic effect. Can be used to relieve pain and inflammation caused by gout.

Description

technical field [0001] The invention relates to the technical field of medicine, and belongs to the application of an active substance extracted from Cordyceps fungus (or artificially synthesizing the active substance) for anti-inflammatory and analgesia in gout disease. Background technique [0002] Gout is a metabolic disease caused by the continuous increase of serum uric acid concentration leading to the deposition of urate crystals in soft tissues. The onset of gout is rapid, accompanied by red, swollen and hot pain, more than at night. The pain can wake people up from sleep. Most of the affected joints are the metatarsal toes or the thumb. In the early stage of the onset, there is usually a single arthritis, and local hyperalgesia occurs after a few hours. and limited activities, which can lead to disability later. Its incidence is increasing year by year to 1-2% and it is younger (So 2008), causing a huge burden to people's lives. Colchicine and non-steroidal anti-i...

AI Technical Summary

Problems solved by technology

N 6 -(2-Hydroxyethyl)adenosine (HEA) is an active compound isolated from Cordyceps cicadae. Although its anti-inflammatory and analgesic effects have also been reported, it has not been reported in the field of gout treatment

Images