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Ion separator and method of ambient ionization mass spectrometry

A technology of ionization mass spectrometry and ion separation, which is applied in the direction of electron/ion optical devices, measuring devices, parts of particle separator tubes, etc. It can solve problems such as high background signal of mass spectrometry, inability to obtain sample retention time, complex detection components, etc. , to achieve the effects of reducing background interference, reliable identification and quantification, and simplified spectra

Pending Publication Date: 2018-08-21
CHINA INNOVATION INSTR CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] This type of analytical technique mainly has the following disadvantages: (1) The detected components entering the mass spectrum are relatively complex, and the background signal of the obtained mass spectrum is high; (2) the retention time of the sample cannot be obtained without chromatographic separation, and it is difficult to analyze the isomers distinguish

Method used

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  • Ion separator and method of ambient ionization mass spectrometry

Examples

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Effect test

Embodiment 1

[0028] figure 1 Schematically shows the structure diagram of the ion separation device of the open ionization mass spectrometer in Example 1 of the present invention, as figure 1 Shown, described ion separation device comprises:

[0029] An insulating tube 1, a straight-through structure with openings at both ends of the insulating tube;

[0030] The first grid ion gate 4, the first grid ion gate is arranged in the insulating tube;

[0031] A second grid ion gate 2, the second grid ion gate is arranged upstream of the first grid ion gate on the ion travel channel;

[0032] An electrode 3, the electrode is arranged in the insulating tube, and is between the first grid ion gate and the second grid ion gate;

[0033] a migration ring 5, the migration ring is arranged in the insulating tube, and is downstream of the first grid ion gate on the ion traveling channel;

[0034] A shielding grid 6, the shielding grid is arranged downstream of the migration ring on the ion travel ch...

Embodiment 2

[0047] An application example of the ion separation device and method according to Embodiment 1 of the present invention.

[0048] In this application example, the second grid ion gate is arranged and connected to the end of the insulating tube; the gas inlet is arranged on the end of the insulating tube away from the second grid ion gate; The electrode is a ring-shaped mechanism; the gas outlet is arranged on the insulating tube between the electrode and the first grid ion gate; the number of the transfer rings is 4-9, uniformly arranged; the gas inlet and the gas outlet are controlled Flow, flow ratio is between 1.66:1 and 10:1.

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Abstract

The invention provides an ion separator and a method of ambient ionization mass spectrometry. The ion separator comprises an insulating tube with two openings on the two ends; a first grating ion gatearranged in the insulating tube; a second grating ion gate arranged in an ion travelling channel at the upstream of the first grating ion gate; an electrode arranged in the insulating tube between the first grating ion gate and the second grating ion gate; an migration ring which is arranged in the insulating tube, in the ion travelling channel at the downstream of the first grating ion gate; anda shield grid which is arranged in the ion travelling channel at the downstream of the migration ring. In applications, gas passes through a gas inlet and the shield grid, and enters into the insulating tube; a gas outlet is arranged on the insulating tube between the first grating ion gate and the second grating ion gate. The ion separator is high in resolution, high in separation efficiency, and is low in background interference.

Description

technical field [0001] The invention relates to mass spectrometry, in particular to an ion separation device and method for an open ionization mass spectrometer. Background technique [0002] Open ionization mass spectrometry is a newly emerging mass spectrometry technique in recent years that directly ionizes surface substances in an open atmospheric pressure environment. Atmospheric pressure open ionization (AI) technology has high matrix tolerance, and can directly ionize analytes in complex matrix samples without (or only a small amount of) sample pretreatment and pre-separation. Therefore, it can be said that the emergence of AI has freed mass spectrometry technology from the limitations of relying heavily on sample pretreatment and chromatographic separation in the past, making it an on-site analytical tool that can give full play to its high-throughput, high-sensitivity and qualitatively accurate technology Advantages, to achieve fast, accurate, high-throughput scree...

Claims

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Application Information

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IPC IPC(8): G01N27/62G01N1/28H01J49/06
CPCH01J49/06G01N1/28G01N27/623
Inventor 闻路红宁录胜赵鹏周峰洪欢欢胡舜迪
Owner CHINA INNOVATION INSTR CO LTD