A pharmaceutical composition with hypolipidemic effect and preparation method thereof

A composition and blood lipid-lowering technology, applied in the direction of drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems that are not conducive to improving the active ingredients of drugs, slow effect, etc., to achieve the benefits of human body absorption and rapid effect , Good for sanitation and environmental protection

Active Publication Date: 2021-02-19
HUNAN XINHUI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the composition has many components, and the treatment only starts from lowering blood sugar, but fails to regulate the function of viscera in a deep level by regulating blood sugar and blood lipids and cooperating with promoting blood circulation and removing blood stasis, and the preparation method is conventional, which is not conducive to improving the active ingredients of the drug, which in turn leads to slow effect

Method used

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  • A pharmaceutical composition with hypolipidemic effect and preparation method thereof
  • A pharmaceutical composition with hypolipidemic effect and preparation method thereof
  • A pharmaceutical composition with hypolipidemic effect and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] 1) Take 800g of Polygonatum biotransformation mycelium, add water to extract 3 times at 50°C, add 3200g of water each time, and extract with water for 2 hours each time, filter the obtained extract, concentrate, freeze-dry, The freeze-dried powder of Polygonatum biotransformation mycelium is obtained after pulverization under the condition of -5~-10°C;

[0037] 2) Take 100g of Panax notoginseng ultrafinely pulverized, and pass through a 200-mesh sieve to obtain Panax notoginseng superfine powder;

[0038] 3) Take 200g of Ligustrum lucidum, 100g of Salvia miltiorrhiza and 100g of hawthorn, add water and extract 3 times at 50°C, extract for 1 hour each time, add 1600g of water each time, filter the obtained extract, concentrate, and spray dry Obtain dry extract powder;

[0039] 4) Uniformly mixing the obtained Polygonatum biotransformation mycelia freeze-dried powder, superfine powder of Panax notoginseng and dry extract powder to obtain a pharmaceutical composition.

Embodiment 2

[0041] 1) Take 1000g of Polygonatum biotransformation mycelium, add water to extract 3 times at 50°C, add 6000g of water each time, and extract with water for 2 hours each time, filter the obtained extract, concentrate, freeze-dry, The freeze-dried powder of Polygonatum biotransformation mycelium is obtained after pulverization under the condition of -5~-10°C;

[0042] 2) Take 200g of Panax notoginseng ultrafinely pulverized, and pass through a 200-mesh sieve to obtain Panax notoginseng superfine powder;

[0043] 3) Take 400g of Ligustrum lucidum, 200g of Salvia miltiorrhiza and 200g of hawthorn, add water to extract 3 times at 50°C, extract 1 hour each time, add water 4800g each time, filter the obtained extract, concentrate, and spray dry Obtain dry extract powder;

[0044] 4) Uniformly mixing the obtained Polygonatum biotransformation mycelia freeze-dried powder, superfine powder of Panax notoginseng and dry extract powder to obtain a pharmaceutical composition.

Embodiment 3

[0046] 1) Take 1200g of Polygonatum biotransformation mycelia, add water to extract 3 times at 60°C, add 96,000g of water each time, and extract with water for 5 hours each time, filter the obtained extract, concentrate, freeze-dry, The freeze-dried powder of Polygonatum biotransformation mycelium is obtained after pulverization under the condition of -5~-10°C;

[0047] 2) Take 300g of Panax notoginseng ultrafinely pulverized, and pass through a 200-mesh sieve to obtain Panax notoginseng superfine powder;

[0048] 3) Take 600g of Ligustrum lucidum, 300g of Salvia miltiorrhiza and 300g of hawthorn, add water to extract 3 times at 50°C, extract for 1 hour each time, add water 108000g each time, filter the obtained extract, concentrate, and spray dry Obtain dry extract powder;

[0049] 4) Uniformly mixing the obtained Polygonatum biotransformation mycelia freeze-dried powder, superfine powder of Panax notoginseng and dry extract powder to obtain a pharmaceutical composition.

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Abstract

The invention discloses a pharmaceutical composition, which is composed of the following raw materials in parts by weight: 8-12 parts of Polygonatum biotransformed mycelia, 2-6 parts of Ligustrum lucidum, 1-3 parts of Salvia miltiorrhiza, 1-3 parts of Panax notoginseng, 1 to 3 parts of hawthorn; the preparation method comprises the following steps: taking Polygonatum biotransformation mycelia, adding water for extraction, filtering the obtained extract, concentrating, freeze-drying, and crushing at low temperature to obtain freeze-dried powder; taking Panax notoginseng supernatant Finely pulverize to obtain superfine powder of notoginseng; take Ligustrum lucidum, Salvia miltiorrhiza and hawthorn, add water to extract, filter, concentrate, and spray dry the extract to obtain dry extract powder; freeze-dried powder, superfine powder of notoginseng and dry extract The powder is mixed uniformly to obtain a composition. The invention provides a medicinal composition for treating diabetic nephropathy with good curative effect, no toxic and side effects, and the effect of lowering blood fat.

Description

technical field [0001] The invention relates to the technical field of medical products, in particular to a pharmaceutical composition and a preparation method thereof. Background technique [0002] Diabetic nephropathy is one of the most important comorbidities in diabetic patients. The incidence rate in my country is also on the rise, and it has become the second cause of end-stage renal disease, second only to various glomerulonephritis. Due to its complex metabolic disorders, once it develops into end-stage renal disease, it is often more difficult to treat than other kidney diseases. Therefore, timely prevention and treatment is of great significance for delaying diabetic nephropathy. The "invisible killer" of diabetic patients is cholesterol. For every 1 mmol / l increase in cholesterol, the risk of cardiovascular disease increases by 57%. The cholesterol family has four major members: 1. Triglycerides are related to cardiovascular and cerebrovascular diseases; 2. The ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8969A61P3/10A61P13/12A61P3/06
CPCA61K36/258A61K36/537A61K36/638A61K36/734A61K36/8969A61K2236/19A61K2236/331A61K2236/39A61K2236/51A61P3/06A61P3/10A61P13/12A61K2300/00
Inventor 何述金周代俊何承东
Owner HUNAN XINHUI PHARMA
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