A kind of biflavonoid compound and its application

A kind of technology of biflavonoids and composition of Suicha spica, which is applied in the field of pharmacy, and can solve the problem of enhancing carboplatin damage and other problems

Active Publication Date: 2020-06-23
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The results showed that C-3′-C-8″ biflavonoid compounds can significantly enhance the damage effect of carboplatin on cancer cells, while monoflavone (8) and other linking biflavonoid compounds (9-10) have no Synergistic sensitization (Table 2)

Method used

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  • A kind of biflavonoid compound and its application
  • A kind of biflavonoid compound and its application
  • A kind of biflavonoid compound and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1 In Vitro Cell Activity Screening of Cedarwood Diflavonoids

[0022] 1.1 Test materials and instruments

[0023] 1.1.1 Test materials

[0024] A549 cells, HepG2 cells, Ovarian cells (BRCA gene defective) Shanghai Chinese Academy of Sciences cell bank; nude mice, Nanjing University Model Animal Center; DMEM medium, Nanjing KGI Biotechnology Development Co., Ltd.; Fetal bovine serum, American ScienCell; double Anti-(penicillin, streptomycin) Nanjing KGI Biotechnology Co., Ltd.; Trypan Blue, Canadian BioBasic Co., Ltd.; Thiazol Blue (methyl thiazolyl tetrazolium, MTT), Nanjing KGI Biotechnology Development Co., Ltd.; Cephalosporium biflavonoids and Its structural analogues were isolated from S. Mollendorfii, and the structure was identified by NMR, MS and other spectroscopic methods. The purity was all> 95%.

[0025] 1.1.2 Test equipment:

[0026] Microplate reader, Tecan, Switzerland; inverted fluorescence microscope, Nikon, Japan

[0027] 1.2 Test methods and results

[0...

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PUM

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Abstract

The invention discloses a biflavonoid compound and application thereof, belongs to the field of natural pharmaceutical chemistry and pharmacotherapy, and particularly relates to a C-3'-C-8''-type biflavonoid compound or pharmaceutically acceptable salt thereof, a pharmaceutical composition containing the compound, medical application thereof, particularly application thereof as a chemotherapeuticplatinum medicine sensitizer, and a therapeutic effect on BRCA gene defect-type advanced ovarian cancer.

Description

Technical field [0001] The invention relates to a C-3'-C-8" type diflavonoid compound, and its application in the treatment of liver cancer and lung cancer chemotherapy platinum drug sensitization, and for BRCA gene defect advanced ovarian cancer The therapeutic effect belongs to the field of pharmacy technology. Background technique [0002] Malignant tumors seriously endanger human life and health and have become one of the main causes of death from diseases today. At present, the main treatment methods for malignant tumors include surgery, radiotherapy and chemotherapy. Chemotherapy is a better choice for patients diagnosed with advanced tumors and patients who have already metastasized. Clinicians can optimize the maximum curative effect and minimum toxicity by adjusting the dosage of the drug, help patients prolong survival time and improve prognostic quality of life. However, the drug resistance of tumor cells leads to a decrease in the sensitivity of tumor cells to chem...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/352A61K33/24A61K31/555A61P35/00
CPCA61K31/352A61K31/555A61K33/24A61P35/00C07D311/30A61K2300/00
Inventor 汪豪胡晓龙熊非叶文才
Owner CHINA PHARM UNIV
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