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Method for preparing congenital cleft palate animal model

An animal model, congenital technology, applied in the direction of pharmaceutical formulations, organic active ingredients, medical preparations containing active ingredients, etc., to achieve the effect of large operable range, withstand surgical trauma, and strong vitality

Pending Publication Date: 2018-10-02
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in the prior art, there is no method to construct a stable congenital cleft palate rabbit model

Method used

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  • Method for preparing congenital cleft palate animal model
  • Method for preparing congenital cleft palate animal model
  • Method for preparing congenital cleft palate animal model

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Embodiment 1

[0019] 1. Adopt the method of the present invention to prepare congenital cleft palate animal model

[0020] Five New Zealand pregnant rabbits were used to prepare the animal model of congenital cleft palate. Each New Zealand pregnant rabbit was fed separately in a rabbit cage, and the relative humidity of the room where the pregnant rabbit was raised was kept at 40%-70%, and the temperature was 20-27°C. From the 13th day of pregnancy (GD13) to the 16th day of pregnancy (GD16), at 8:00 every morning, intramuscularly inject 1.0 mg of dexamethasone (dexamethasone sodium phosphate injection, Tianjin, China) into the quadriceps muscle of each pregnant rabbit. Pregnant rabbits were raised until they gave birth naturally, and pups were obtained. The number of surviving fetuses, stillbirths and offspring with cleft palate were recorded, and the morphology of cleft palate was observed.

[0021] The results are shown in Table 1. 5 pregnant rabbits gave birth naturally, of which 0 wer...

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Abstract

The invention provides a method for preparing a congenital cleft palate animal model, and relates to the field of animal models of oral diseases. The preparation method comprises the following steps:pregnant rabbits are treated with dexamethasone for intervention every day for 13 days to 16 days of pregnancy, the pregnant rabbits are fed to production, and offspring rabbits are congenital cleft palate models. The method can efficiently construct the morphologically stable congenital cleft rabbit model, thereby providing a model basis for further clinical research of cleft palate.

Description

technical field [0001] The invention relates to the field of oral disease animal models, in particular to a method for preparing an animal model of congenital cleft palate. Background technique [0002] Currently, animal models used for cleft palate research include animal models with congenital cleft palate and surgically produced animal models. The former is a congenital model, which is mainly used to study the etiology and pathogenesis of cleft palate. The commonly used animal models include monkeys, goats, rats, etc.; the latter is a traumatic model made by surgery, which is mostly used to explore the clinical treatment of cleft palate. Models include rabbits, dogs, cats, etc. [0003] Although the use of surgery to create palate clefts can standardize the shape of the cleft, it is often used in clinical surgery or postoperative growth research, but such clefts cannot simulate congenital palate clefts, and surgical clefts in large animals are also vulnerable to ethical ...

Claims

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Application Information

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IPC IPC(8): A61K31/573
CPCA61K31/573
Inventor 李承浩石冰蒲玲玲
Owner SICHUAN UNIV
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