Preparation and application of N-(2-hydroxy-5-chlorobenzene)ylrhodamine B hydrazide
A technology of hydrazide and chlorobenzene, which is applied in the field of easy preparation of rhodamine B derivative fluorescent sensing materials, can solve the problems of complex zinc ion identification and detection methods, low identification response sensitivity, and cumbersome processes, and achieve raw materials Less dosage, good recognition selectivity and high optical activity
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Embodiment 1
[0026] (1) Dissolve 1.2g (2.5mmol) of Rhodamine B in ethanol solvent, add 2mL of 80% hydrazine hydrate, heat and reflux at 80°C for 3 hours, concentrate the solvent, and precipitate a yellow product, filter it with suction, dry it and put it in In a small beaker, continuously drop concentrated hydrochloric acid to dissolve the product completely into a purple-red solution, then adjust the pH value of the system to about 7.0 with 40% aqueous sodium hydroxide solution, and a large amount of light pink solid is precipitated. After suction filtration and drying, light pink rhodamine is obtained. B hydrazide intermediate product powder;
[0027] (2) Dissolve 0.456g (1mmol) of the intermediate product in step (1) in methanol and add 0.133g (0.8mmol) of 5-chlorosalicylaldehyde. After refluxing at 50°C for 28 hours, a white solid precipitates and cools to room temperature. Afterwards, suction filtration, washing, vacuum drying at 40°C for 12 hours, and finally recrystallization twice ...
Embodiment 2
[0029] (1) Dissolve 1.2g (2.5mmol) of rhodamine B in ethanol solvent, add 4mL of 80% hydrazine hydrate, heat and reflux at 90°C for 1 hour, concentrate the solvent, and precipitate a yellow product, filter it with suction, dry it and put it in In a small beaker, continuously drop concentrated hydrochloric acid to dissolve the product completely into a purple-red solution, then adjust the pH value of the system to about 7.0 with 40% aqueous sodium hydroxide solution, and a large amount of light pink solid is precipitated. After suction filtration and drying, light pink rhodamine is obtained. B hydrazide intermediate product powder;
[0030] (2) Dissolve 0.456g (1mmol) of the intermediate product in step (1) in methanol and add 0.199g (1.2mmol) of 5-chlorosalicylaldehyde. After refluxing at 70°C for 20 hours, a white solid precipitates and cools to room temperature. Afterwards, suction filtration, washing, vacuum drying at 50°C for 8 hours, and finally recrystallization twice wi...
Embodiment 3
[0032] (1) Dissolve 1.2g (2.5mmol) of rhodamine B in ethanol solvent, add 3mL of 80% hydrazine hydrate, heat and reflux at 85°C for 2 hours, concentrate the solvent, and precipitate a yellow product, filter it with suction, dry it and put it in In a small beaker, continuously drop concentrated hydrochloric acid to dissolve the product completely into a purple-red solution, then adjust the pH value of the system to about 7.0 with 40% aqueous sodium hydroxide solution, and a large amount of light pink solid is precipitated. After suction filtration and drying, light pink rhodamine is obtained. B hydrazide intermediate product powder;
[0033] (2) Dissolve 0.456g (1mmol) of the intermediate product in step (1) in methanol and add 0.166g (1.0mmol) of 5-chlorosalicylaldehyde. After reflux at 60°C for 24 hours, a white solid is precipitated and cooled to room temperature. Afterwards, suction filtration, washing, vacuum drying at 45°C for 10 hours, and finally recrystallization twice...
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