Traditional Chinese medicine with tracing effect

Abstract

The invention provides a traditional Chinese medicine with a tracing effect and the application thereof to pharmacological traditional Chinese medicine research, and belongs to the technical field ofmedicines. The invention adopts a specific technical scheme as follows: through a chemical means, a contrast agent and the main component of the traditional Chinese medicine are combined into a macromolecule having a therapeutic effect of the traditional Chinese medicine and a developing effect of a developing agent, so that distribution and aggregation of the traditional Chinese medicine in a body can be detected in CT or MR, therefore, the acting site and the medicinal efficacy of the traditional Chinese medicine are confirmed and the acting principle of the traditional Chinese medicine hasa scientific medical evidence. In particular, the combination of icariin and gadopentetate meglumine through a chemical reaction plays an important significance on studying the effect of the icariin on chondrocytes and the therapeutic effect thereof on knee joint diseases.

Description

Technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a traditional Chinese medicine with a tracer effect and its application in the pharmacological research of traditional Chinese medicine. Background technique [0002] As a non-invasive soft tissue imaging technology, NMR has been widely used in clinics, especially for nerves, muscles, cartilage, tumors and other tissues. As an advanced medical imaging diagnostic technology, it uses different tissues of the organism to produce different resonance signals under the influence of external magnetic fields. The strength of the magnetic resonance signal depends on the content of water in the tissue and the relaxation time of protons in water molecules. It can effectively detect tissue necrosis, ischemia and various malignant lesions such as tumors, and can make early diagnosis, and can also monitor organ transplantation. The use of nuclear magnetic contrast agent increases tissu...

AI Technical Summary

Problems solved by technology

[0008] Observation of the effect of traditional Chinese medicine on cartilage in the body mainly adopts at present: 1. After the experiment, the animal is put to death to carry out inspections on aspects such as histomorphology, immunity, and biochemistry. 2. Do radioactive labeling of traditional Chinese medicine

The disadvantage is that there is radiation, and drugs need special procurement, storage, and processing, which are difficult for general laboratories to complete

[0009] We have proved the effect of traditional Chinese medicine, taking icariin as an example, on animal cartilage in vitro through preliminary experiments, but how to non-invasively observe the effect of traditional Chinese medicine on animal cartilage in vivo (first consider the absorption, distribution, and metabolism of the drug) etc.) has not been reported in the literature

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