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Traditional Chinese medicine with tracing effect

A technology of traditional Chinese medicine and function, applied in the field of medicine, can solve the problems of not reflecting the biotransformation process of traditional Chinese medicine, low animal utilization rate, and no literature reports.

Inactive Publication Date: 2018-10-09
天津中医药大学第一附属医院
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Problems solved by technology

[0008] Observation of the effect of traditional Chinese medicine on cartilage in the body mainly adopts at present: 1. After the experiment, the animal is put to death to carry out inspections on aspects such as histomorphology, immunity, and biochemistry. 2. Do radioactive labeling of traditional Chinese medicine
The disadvantage is that there is radiation, and drugs need special procurement, storage, and processing, which are difficult for general laboratories to complete
[0009] We have proved the effect of traditional Chinese medicine, taking icariin as an example, on animal cartilage in vitro through preliminary experiments, but how to non-invasively observe the effect of traditional Chinese medicine on animal cartilage in vivo (first consider the absorption, distribution, and metabolism of the drug) etc.) has not been reported in the literature

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Embodiment Construction

[0035] Taking the combination of icariin and the nuclear magnetic contrast agent gadopentetate meglumine as an example to illustrate the technical scheme of the present invention.

[0036] Gadopentetate meglumine (Gd-DTPA) is connected with icariin to form a macromolecular complex with a molecular weight of more than 2000 Daltons. This binding molecule has two advantages: one is that it stays in the blood vessel for a longer time, and the other is Conducive to imaging; the other is to use the affinity of drugs to tissues, which can make the target tissues more clearly visible and evaluate its drug intake and tissue organ function.

[0037] Taking the kidney as an example, the role of the binding molecule is to specifically bind to target cells in the kidney to take up the specific distribution in different tissues in the kidney, thereby improving the detection rate of minimal changes in the kidney and the accuracy of qualitative diagnosis. . Strong magnetic activity, good safety p...

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Abstract

The invention provides a traditional Chinese medicine with a tracing effect and the application thereof to pharmacological traditional Chinese medicine research, and belongs to the technical field ofmedicines. The invention adopts a specific technical scheme as follows: through a chemical means, a contrast agent and the main component of the traditional Chinese medicine are combined into a macromolecule having a therapeutic effect of the traditional Chinese medicine and a developing effect of a developing agent, so that distribution and aggregation of the traditional Chinese medicine in a body can be detected in CT or MR, therefore, the acting site and the medicinal efficacy of the traditional Chinese medicine are confirmed and the acting principle of the traditional Chinese medicine hasa scientific medical evidence. In particular, the combination of icariin and gadopentetate meglumine through a chemical reaction plays an important significance on studying the effect of the icariin on chondrocytes and the therapeutic effect thereof on knee joint diseases.

Description

Technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a traditional Chinese medicine with a tracer effect and its application in the pharmacological research of traditional Chinese medicine. Background technique [0002] As a non-invasive soft tissue imaging technology, NMR has been widely used in clinics, especially for nerves, muscles, cartilage, tumors and other tissues. As an advanced medical imaging diagnostic technology, it uses different tissues of the organism to produce different resonance signals under the influence of external magnetic fields. The strength of the magnetic resonance signal depends on the content of water in the tissue and the relaxation time of protons in water molecules. It can effectively detect tissue necrosis, ischemia and various malignant lesions such as tumors, and can make early diagnosis, and can also monitor organ transplantation. The use of nuclear magnetic contrast agent increases tissu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H23/00A61P19/02A61P19/00A61K49/10
CPCA61K49/0004A61K49/106C07H23/00
Inventor 张君涛赵瑾尚曼吕喆李思迪毕海吴超超
Owner 天津中医药大学第一附属医院
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